Severe and Cerebral Malaria Investigated Through Host Metabolomics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

840 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2017-09-30

Brief Summary

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* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
* Despite treatment between 10-30% of patients with severe malaria die.
* Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
* Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

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Detailed Description

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Conditions

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Severe Malaria

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Severe/Cerebral Malaria

Intensive monitoring

Observation

Intervention Type OTHER

Uncomplicated Malaria

Intensive monitoring

Observation

Intervention Type OTHER

Sepsis

Intensive monitoring

Observation

Intervention Type OTHER

Acidosis

Intensive monitoring

Observation

Intervention Type OTHER

Encephalitis

Intensive monitoring

Observation

Intervention Type OTHER

Healthy Individuals

Monitoring

Observation

Intervention Type OTHER

Interventions

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Observation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 12 years
* Full informed written consent obtained

Encephalitis:

* GCS \< 11/15
* Documented fever \> 38°C
* Onset of symptoms \< 2 weeks, with an indication a lumbar puncture as part of the diagnostic work up
* Negative peripheral blood slide for any stages of malaria parasites or a negative rapid diagnostic test for falciparum and vivax malaria
* Age \> 12 years
* Full informed written consent obtained

Healthy volunteers:

* No chronic or acute disease
* No fever in the past 2 weeks
* Age \> 16 years
* Full informed written consent obtained