Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)

NCT ID: NCT02448745

Last Updated: 2018-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6317 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-01

Study Completion Date

2017-04-01

Brief Summary

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A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia. Half of the villages enrolled in the study will receive insecticide-treated wall lining covering their walls and ceilings in addition to long-lasting insecticidal nets, while the other half will be protected by existing long-lasting insecticidal nets.

Detailed Description

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Long-lasting insecticidal nets (LLINs) are the established vector control product for malaria control. In Bomi County Liberia, LLINs have been distributed but malaria prevalence in children under 5 remains high, with prevalence in study villages found to be 42% in April 2014. The major malaria vector species are resistant to pyrethroid insecticides approved for use in LLINs, and new control measures with non-pyrethroid active ingredients may protect the population.

Conditions

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Malaria, Falciparum Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Control

21 clusters composed of one or more villages with a total number of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is the only malaria control intervention.

Group Type NO_INTERVENTION

No interventions assigned to this group

Intervention

21 clusters composed of one or more villages with a total of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is available and in addition insecticide treated wall lining is installed in all sleeping areas with homeowner consent. All 4 walls and the ceiling are covered with lining.

Group Type EXPERIMENTAL

Insecticide treated wall lining

Intervention Type DEVICE

Polypropylene non-woven fabric.

Interventions

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Insecticide treated wall lining

Polypropylene non-woven fabric.

Intervention Type DEVICE

Other Intervention Names

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Durable wall lining PermaNet Lining

Eligibility Criteria

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Inclusion Criteria

* Child resides in village
* Child presents with parent or guardian

Exclusion Criteria

* Child or guardian has history of Ebola exposure
* Child has 3 symptoms of Ebola
Minimum Eligible Age

2 Months

Maximum Eligible Age

59 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ministry of Health, Liberia

OTHER

Sponsor Role collaborator

The Mentor Initiative

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David J Giesbrecht, MSc

Role: PRINCIPAL_INVESTIGATOR

Study Coordinator

Locations

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Bomi County Health Team

Tubmanburg, Bomi County, Liberia

Site Status

Countries

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Liberia

References

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Giesbrecht D, Belleh TG, Pontarollo J, Hinneh VS, Pratt O, Kamal S, Allan R. Durable wall lining for malaria control in Liberia: results of a cluster randomized trial. Malar J. 2023 Jan 12;22(1):15. doi: 10.1186/s12936-022-04429-7.

Reference Type DERIVED
PMID: 36635660 (View on PubMed)

Related Links

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Other Identifiers

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LiberiaDL

Identifier Type: -

Identifier Source: org_study_id

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