Luma Light System Proof of Concept Study in Subjects With Mild to Moderate Psoriasis

NCT ID: NCT02447068

Last Updated: 2015-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Brief Summary

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This is a proof of concept, investigator blinded study to evaluate the efficacy and safety of a novel combination of a home narrow band ultraviolet B (NBUVB) lamp with an occlusive dressing in adult subjects with mild to moderate psoriasis vulgaris. Four interpatient arms will be used to compare the efficacy of combination of NBUVB with an occlusive dressing to the light alone and to dressing alone and no treatment. Ten patients will be enrolled in this 6 weeks study.

Detailed Description

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Conditions

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Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Non-treatment Control

Control arm will not have any intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Occlusive Dressing

An off-the-shelf dressing occlusive dressing will be used as an active comparator.

Group Type ACTIVE_COMPARATOR

Occlusive Dressing

Intervention Type DEVICE

Off-the-shelf occlusive dressing

Luma Light

A NBUVB light will be used as an active comparator.

Group Type ACTIVE_COMPARATOR

Luma Light

Intervention Type DEVICE

NBUVB light

Luma Light System

The experimental arm will be a combination of an occlusive dressing and NBUVB light.

Group Type EXPERIMENTAL

Luma Light System

Intervention Type DEVICE

The Luma Light System combines a NBUVB light with an occlusive dressing.

Interventions

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Luma Light System

The Luma Light System combines a NBUVB light with an occlusive dressing.

Intervention Type DEVICE

Luma Light

NBUVB light

Intervention Type DEVICE

Occlusive Dressing

Off-the-shelf occlusive dressing

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male or female of any race, 18 to 65 (inclusive) years of age.
* Verbal and written informed consent obtained from the subject.
* Has a clinical diagnosis of mild to moderate psoriasis at the Screening and Baseline visits.
* Has an IGA score of 2 or 3.
* Target plaque assessment (TPA) score between 6-9 and a score of at least 2 for each of the 3 different psoriasis signs and symptoms (erythema, plaque elevation, and scaling)
* Has at least 4 plaques of at least 10 cm2 with TPA scores not differing from each other by a score of more than 1
* Is in good general health as determined by the Investigator based on the subject's medical history, vital signs and physical examination.
* Females of childbearing potential must have negative urine pregnancy test results.
* Females of childbearing potential agree to use acceptable methods of contraception from the screening visit continuously until 30 days after end of treatment.
* Subject agrees to use only the Sponsor provided cleanser and lotion during the study period.
* Subject is willing and able to return for all study visits.

Exclusion Criteria

* Presence of psoriasis that was previously treated with prescription medications prior to the Screening visit and was non-responsive to treatment, as determined by the Investigator.
* Presence of any concurrent skin condition that could interfere with the evaluation of the study device, as determined by the Investigator.
* Female who is pregnant, nursing an infant, or planning a pregnancy during the study period.
* Treatment with any investigational drug or device within 30 days or 5 half-lives (whichever is longer) prior to the Baseline visit, or concurrent participation in another clinical trial with an investigational drug or device.
* History of melanoma.
* Subject has any medical, social or psychological conditions that, in the opinion of the Investigator, preclude them from receiving the pre-treatment, required treatment, and post-treatment procedures and evaluations.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Illumicure Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Redwood Family Dermatology

Santa Rosa, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Liza Marie

Role: CONTACT

707-755-3946

Facility Contacts

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Liza Marie

Role: primary

707-755-3946

Other Identifiers

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L-001

Identifier Type: -

Identifier Source: org_study_id

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