LCD Solution Versus Calcipotriol Cream in the Treatment of Moderate Plaque Psoriasis

NCT ID: NCT00705900

Last Updated: 2008-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2008-11-30

Brief Summary

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The purpose of this study is to compare the safety and effectiveness of a new topical LCD solution and a commercially available calcipotriol (Vitamin D) cream in reducing the symptoms of plaque psoriasis and improving the quality of life in adults.

Detailed Description

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Conditions

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Chronic Plaque Psoriasis

Keywords

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psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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1

LCD Solution: 2 applications / day

Group Type EXPERIMENTAL

LCD

Intervention Type DRUG

2 applications / day for 12 weeks

2

Calcipotriol cream: 2 applications / day

Group Type ACTIVE_COMPARATOR

calcipotriol

Intervention Type DRUG

2 applications / day for 12 weeks

Interventions

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LCD

2 applications / day for 12 weeks

Intervention Type DRUG

calcipotriol

2 applications / day for 12 weeks

Intervention Type DRUG

Other Intervention Names

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Dovonex Cream (50 mcg/g 0.005%)

Eligibility Criteria

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Inclusion Criteria

* 18 years of age or older
* able and willing to provide written informed consent
* diagnosed with chronic plaque psoriasis
* 3% to 15% body surface area involved
* in good general health

Exclusion Criteria

* other current treatments for psoriasis
* renal or liver dysfunction
* pregnant or nursing
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NeoStrata Company, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Massachusettes General Hospital / Brigham Women's Hospital

Principal Investigators

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Alexandra B Kimball, MD

Role: PRINCIPAL_INVESTIGATOR

Massachusettes General Hospital / Brigham Women's Hospital

Locations

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Mass General Hospital: Clinical Unit for Research Trials in Skin

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Alora-Palli MB, Brouda I, Green B, Kimball AB. A cost-effectiveness comparison of liquor carbonis distillate solution and calcipotriol cream in the treatment of moderate chronic plaque psoriasis. Arch Dermatol. 2010 Aug;146(8):919-22. doi: 10.1001/archdermatol.2010.167. No abstract available.

Reference Type DERIVED
PMID: 20713833 (View on PubMed)

Alora-Palli MB, Perkins AC, Van Cott A, Kimball AB. Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: a controlled comparison with calcipotriene (calcipotriol) cream. Am J Clin Dermatol. 2010;11(4):275-83. doi: 10.2165/11530380-000000000-00000.

Reference Type DERIVED
PMID: 20513160 (View on PubMed)

Other Identifiers

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06-LCDPOP

Identifier Type: -

Identifier Source: org_study_id