Observational Study on Plasma Glutamine Levels Before and After Cardiac Surgery

NCT ID: NCT02444780

Last Updated: 2016-02-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-06-30
• Study Completion Date: 2015-11-30

Brief Summary

Earlier studies showed that a low glutamine level at acute admission on the ICU is associated with a poor outcome [3,4]. Recently, we found that a low plasma glutamine is correlated with severity of illness and presence of an infection after non-elective ICU admission [5, submitted].

Detailed Description

It is known that major surgery induces a stress response characterised by hormonal release and inflammatory processes [6,7]. This surgical stress response resembles the catabolic stress which is found in other forms of critical illness. We did not measure plasma glutamine before surgery so it is unknown whether the plasma glutamine level was already low before surgery in these patients or that the lowering of plasma glutamine level is a consequence of surgery. Most of the patients in the elective surgery group in our study underwent cardiac surgery with use of cardiopulmonary bypass; it is known that extracorporeal circulation induces an inflammatory response but there are no clinical data on the effects on plasma glutamine or on post-operative course in relation to plasma glutamine levels [8,9].

Conditions

Glutamin Level

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

elective cardiac surgery patients

consecutive patients who undergo elective cardio-thoracic surgery during a 6 to 8 week period

no intervention, blood is sampled for routine

Intervention Type: PROCEDURE

no intervention, blood sampled for standard evaluation will be used for determination of plasma glutamin

Interventions

no intervention, blood is sampled for routine

no intervention, blood sampled for standard evaluation will be used for determination of plasma glutamin

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• patients undergoing elective cardiac surgery

Exclusion Criteria

• none

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Frisius Medisch Centrum

OTHER

Sponsor Role: lead

Responsible Party

Matty Koopmans

MSc

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hanneke Buter, MD

Role: PRINCIPAL_INVESTIGATOR

MCL

References

Buter H, Koopmans M, Kemperman R, Jekel L, Boerma C. Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study. J Cardiothorac Surg. 2016 Nov 25;11(1):155. doi: 10.1186/s13019-016-0549-1.

Reference Type: DERIVED

PMID: 27884211 (View on PubMed)

Other Identifiers

nWMO 115

Identifier Type: -

Identifier Source: org_study_id