Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy
NCT ID: NCT02439801
Last Updated: 2015-05-12
Study Results
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Basic Information
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COMPLETED
75 participants
OBSERVATIONAL
2015-03-31
2015-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CROSSOVER
PROSPECTIVE
Study Groups
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Compliance
Pulmonary compliance (or lung compliance) is a measure of the lung's ability to stretch and expand. In clinical practice it is separated into two different measurements, static compliance and dynamic compliance. Static lung compliance is the change in volume for any given applied pressure. Dynamic lung compliance is the compliance of the lung at any given time during actual movement of air.
Effects of intra-operative PEEP 0, PEEP 5, PEEP 8 treatment on static and dynamic compliance levels will be investigate.
PEEP 0
0 cmH2O positive end expiratory pressure
PEEP 5
5 cmH2O positive end expiratory pressure
PEEP 8
8 cmH2O positive end expiratory pressure
Pulmonary Function tests
Pulmonary function testing has diagnostic and therapeutic roles and helps clinicians answer some general questions about patients with lung disease.
Effects of intra-operative PEEP 0, PEEP 5, PEEP 8 treatment on pulmonary function test values will be investigate.
PEEP 0
0 cmH2O positive end expiratory pressure
PEEP 5
5 cmH2O positive end expiratory pressure
PEEP 8
8 cmH2O positive end expiratory pressure
volatil agent elimination time
Volatile anaesthetics are eliminated in the terminal phase via the lungs. A low blood:gas partition coefficient is therefore necessary for quick removal of the anaesthetic.
Effects of intra-operative PEEP 0, PEEP 5, PEEP 8 treatment on volatil agent elimination time will be investigate.
PEEP 0
0 cmH2O positive end expiratory pressure
PEEP 5
5 cmH2O positive end expiratory pressure
PEEP 8
8 cmH2O positive end expiratory pressure
Interventions
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PEEP 0
0 cmH2O positive end expiratory pressure
PEEP 5
5 cmH2O positive end expiratory pressure
PEEP 8
8 cmH2O positive end expiratory pressure
Eligibility Criteria
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Inclusion Criteria
* BMI of 25-30
* patients scheduled to elective laparoscopic cholecystectomy.
Exclusion Criteria
* Patients with comorbid diseases that may increase intra-abdominal pressure or pulmonary hypertension,
* Patients with renal and hepatic failure,
* Patients with pregnancy and
* Patients using bronchodilator or steroid were excluded.
30 Years
65 Years
ALL
Yes
Sponsors
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Umraniye Education and Research Hospital
OTHER_GOV
Responsible Party
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Gulsah Karaoren
MD
Principal Investigators
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Nurten Bakan, MD
Role: STUDY_DIRECTOR
Unraniye training hospital
Locations
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Istanbul Umraniye Training Hospital
Istanbul, , Turkey (Türkiye)
Countries
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References
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Karsten J, Heinze H, Meier T. Impact of PEEP during laparoscopic surgery on early postoperative ventilation distribution visualized by electrical impedance tomography. Minerva Anestesiol. 2014 Feb;80(2):158-66. Epub 2013 Jul 23.
Aydin V, Kabukcu HK, Sahin N, Mesci A, Arici AG, Kahveci G, Ozmete O. Comparison of pressure and volume-controlled ventilation in laparoscopic cholecystectomy operations. Clin Respir J. 2016 May;10(3):342-9. doi: 10.1111/crj.12223. Epub 2014 Nov 14.
Ozdilekcan C, Songur N, Berktas BM, Dinc M, Ucgul E, Ok U. Risk factors associated with postoperative pulmonary complications following oncological surgery. Tuberk Toraks. 2004;52(3):248-55.
Other Identifiers
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GK5
Identifier Type: -
Identifier Source: org_study_id
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