Study to Evaluate the Long-Term Safety, Tolerability and Efficacy of Dalfampridine.

NCT ID: NCT02422940

Last Updated: 2019-01-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

294 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2017-01-31

Brief Summary

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This is an extension study to evaluate the long-term safety, tolerability, and efficacy of two dose strengths of dalfampridine-ER.

Detailed Description

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This is an extension study to evaluate the long-term safety, tolerability, and efficacy of two dose strengths of dalfampridine-ER twice daily tablets when administered for at least 12 months to subjects with chronic post-ischemic stroke walking deficits who have completed the controlled, double-blind Study DALF-PS-1016.

Conditions

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Post-ischemic Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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dalfampridine-ER 7.5 mg

Dalfampridine-ER 7.5 mg tablets taken orally twice daily, approximately 12 hours apart.

Subjects who received active treatment in the antecedent core study will retain the dose assignment to which they were initially randomized (7.5 mg or 10 mg dalfampridine-ER tablets). Subjects who received placebo in the core study will be randomly assigned to receive 7.5 mg or 10 mg dalfampridine-ER tablets in this extension study.

Group Type ACTIVE_COMPARATOR

dalfampridine-ER 7.5 mg

Intervention Type DRUG

dalfampridine-ER 10 mg

Dalfampridine-ER 10 mg tablets taken orally twice daily, approximately 12 hours apart.

Subjects who received active treatment in the antecedent core study will retain the dose assignment to which they were initially randomized (7.5 mg or 10 mg dalfampridine-ER tablets). Subjects who received placebo in the core study will be randomly assigned to receive 7.5 mg or 10 mg dalfampridine-ER tablets in this extension study.

Group Type ACTIVE_COMPARATOR

dalfampridine-ER 10 mg

Intervention Type DRUG

Interventions

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dalfampridine-ER 7.5 mg

Intervention Type DRUG

dalfampridine-ER 10 mg

Intervention Type DRUG

Other Intervention Names

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Ampyra™

Eligibility Criteria

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Inclusion Criteria

* Completion of the DALF-PS-1016 study
* Providing informed consent to continue into the DALF-PS-1029 long-term extension study
* Sufficient ambulatory ability to independently complete the Two Minute Walk Test (2MinWT) and 10 Meter Walk Test (10MWT) at the time of enrollment into the extension study

Exclusion Criteria

* Seizures, new onset strokes (or other significant neurological event precluding long-term continuation) occurring during the antecedent DALF-PS-1016 study
* Calculated creatinine clearance of ≤ 50 mL/minute at the time of enrollment into the long-term extension study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Acorda Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Holly Roberts, MD

Role: STUDY_DIRECTOR

Acorda Therapeutics

Locations

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Acorda Site #117

Gilbert, Arizona, United States

Site Status

Acorda Site #109

Berkeley, California, United States

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Acorda Site #170

Carlsbad, California, United States

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Acorda Site #138

Long Beach, California, United States

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Acorda Site #105

Newport Beach, California, United States

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Acorda Site #142

Pasadena, California, United States

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Acorda Site #153

Sacramento, California, United States

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Acorda Site #151

San Diego, California, United States

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Acorda Site #163

San Diego, California, United States

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Acorda Site #124

Colorado Springs, Colorado, United States

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Acorda Site #110

Danbury, Connecticut, United States

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Acorda Site #149

Fairfield, Connecticut, United States

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Acorda Site #130

Stamford, Connecticut, United States

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Acorda Site #115

Atlantis, Florida, United States

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Acorda Site #119

Deerfield Beach, Florida, United States

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Acorda Site #147

Gainesville, Florida, United States

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Acorda Site #128

Hialeah, Florida, United States

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Acorda Site #184

Jacksonville, Florida, United States

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Acorda Site #103

Miami, Florida, United States

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Acorda Site #133

Miami, Florida, United States

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Acorda Site #161

Naples, Florida, United States

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Acorda Site #106

Tampa, Florida, United States

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Acorda Site #181

Honolulu, Hawaii, United States

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Acorda Site #171

Chicago, Illinois, United States

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Acorda Site #148

Avon, Indiana, United States

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Acorda Site #188

Fort Wayne, Indiana, United States

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Acorda Site #156

Franklin, Indiana, United States

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Acorda Site #146

Lexington, Kentucky, United States

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Acorda Site #150

New Orleans, Louisiana, United States

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Acorda Site #175

Fulton, Maryland, United States

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Acorda Site #136

Boston, Massachusetts, United States

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Acorda Site #121

Boston, Massachusetts, United States

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Acorda Site #123

East Lansing, Michigan, United States

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Acorda Site #164

Farmington Hills, Michigan, United States

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Acorda Site #159

Grand Rapids, Michigan, United States

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Acorda Site #101

Kansas City, Missouri, United States

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Acorda Site #111

Great Falls, Montana, United States

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Acorda Site #140

Reno, Nevada, United States

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Acorda Site #131

New Brunswick, New Jersey, United States

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Acorda Site #177

Stratford, New Jersey, United States

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Acorda Site #172

New York, New York, United States

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Acorda Site #179

Patchogue, New York, United States

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Acorda Site #114

White Plains, New York, United States

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Acorda Site #166

Chapel Hill, North Carolina, United States

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Acorda Site #167

Durham, North Carolina, United States

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Acorda Site #162

Mooresville, North Carolina, United States

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Acorda Site #154

Raleigh, North Carolina, United States

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Acorda Site #132

Winston-Salem, North Carolina, United States

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Acorda Site #137

Columbus, Ohio, United States

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Acorda Site #116

Dayton, Ohio, United States

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Acorda Site #152

Corvallis, Oregon, United States

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Acorda Site #168

Portland, Oregon, United States

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Acorda Site #126

Portland, Oregon, United States

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Acorda Site #122

Philadelphia, Pennsylvania, United States

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Acorda Site #144

Providence, Rhode Island, United States

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Acorda Site #157

Memphis, Tennessee, United States

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Acorda Site #113

Dallas, Texas, United States

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Acorda Site #165

Dallas, Texas, United States

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Acorda Site #108

Houston, Texas, United States

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Acorda Site #182

Falls Church, Virginia, United States

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Acorda Site #176

Richmond, Virginia, United States

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Acorda Site #107

Spokane, Washington, United States

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Acorda Site #203

Fredericton, New Brunswick, Canada

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Acorda Site #202

Halifax, Nova Scotia, Canada

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Acorda Site #201

Greenfield Park, Quebec, Canada

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Acorda Site #204

Montreal, Quebec, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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DALF-PS-1029

Identifier Type: -

Identifier Source: org_study_id

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