Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

NCT ID: NCT02415036

Last Updated: 2022-10-17

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-06-30
• Study Completion Date: 2018-12-31

Brief Summary

This is a two arm, open label, multi-center, Phase 2 study to evaluate the efficacy and safety of Melphalan/HDS in patients with unresectable Hepatocellular Carcinoma (HCC) or Intra Hepatic Cholangiocarcinoma (ICC) confined to the liver.

Detailed Description

This is a two arm, open label, multi-center, Phase 2 study to evaluate the efficacy and safety of Melphalan/HDS in patients with unresectable HCC or ICC confined to the liver.

Eligible patients will receive up to 2 Melphalan/HDS treatments. Each treatment cycle consists of 6 weeks with an acceptable delay for another 2 weeks before next planned treatment. Tumor response will be assessed at the end of cycle 2.

The Melphalan/HDS treatment will be terminated in patients with progressive disease (PD) after the 1st treatment and based on safety in patients with > 8 weeks delay of recovery from toxicity.

Conditions

Hepatocellular Carcinoma; Intrahepatic Cholangiocarcinoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Melphalan/HDS treatment of patients with HCC

Percutaneous hepatic perfusion with melphalan hydrochloride for injection using the Hepatic Delivery System on patients with Hepatocellular carcinoma (HCC).

Melphalan hydrochloride is administered at a dose of 3mg/kg ideal body weight once every 6 weeks for a maximum of 2 cycles of treatment.

Group Type: EXPERIMENTAL

Delcath Hepatic Delivery System

Intervention Type: DEVICE

Melphalan

Intervention Type: DRUG

Melphalan/HDS treatment of patients with ICC

Percutaneous hepatic perfusion with melphalan hydrochloride for injection using the Hepatic Delivery System on patients with Intrahepatic cholangiocarcinoma (ICC).

Melphalan hydrochloride is administered at a dose of 3mg/kg ideal body weight once every 6 weeks for a maximum of 2 cycles of treatment.

Group Type: EXPERIMENTAL

Delcath Hepatic Delivery System

Intervention Type: DEVICE

Melphalan

Intervention Type: DRUG

Interventions

Delcath Hepatic Delivery System

Intervention Type: DEVICE

Melphalan

Intervention Type: DRUG

Other Intervention Names

Melphalan/Hepatic Delivery System; Percutaneous hepatic perfusion (PHP)

Eligibility Criteria

Inclusion Criteria

Patients with HCC must meet all of the following criteria for study entry:

1. HCC diagnosed by tissue or imaging study.

2. Unresectable HCC without clinically significant extra hepatic disease (minor lesions [≤ 1 cm and not consistent with metastatic disease] acceptable) based on computed tomography (CT).

3. At least one target lesion based on mRECIST. In patients with prior loco-regional therapy, the target lesion(s) must be located in area(s) outside previous treatment or must have progressed after prior treatment if located within previous treatment field.

4. Child-Pugh Class A.

5. ECOG PS 0-1.

6. No prior radiation therapy to the liver including Y90-, I131-based loco-regional therapy. Prior loco regional therapy, including resection, based on other technology for HCC, if any, must have been completed at least 4 weeks prior to baseline imaging.

7. Age ≥ 18 years.

8. Signed informed consent.

Patients with ICC must meet all of the following criteria for study entry:

1. ICC diagnosed by tissue or imaging study.

2. Unresectable ICC without clinically significant extra hepatic disease (minor lesions [≤ 1 cm and not consistent with metastatic disease] acceptable) based on CT.

3. At least one target lesion based on mRECIST. In patients with prior loco regional therapy, the target lesion(s) must be located in area(s) outside previous treatment or must have progressed after prior treatment if located within previous treatment field.

4. Child-Pugh Class A.

5. ECOG PS 0-1.

6. No prior radiation therapy to the liver including Y90 , I131 based loco regional therapy. Prior loco regional therapy, including resection, based on other technology for ICC, if any, must have been completed at least 4 weeks prior to baseline imaging.

7. Age ≥ 18 years.

8. Signed informed consent.

Exclusion Criteria

For the HCC cohort, patients for whom transplantation, radiofrequency ablation (RFA), transarterial chemoembolization (TACE), or systemic treatment with sorafenib are better therapeutic options are to be excluded from study entry.

Additionally, for both the HCC and ICC cohorts, patients who meet any of the following criteria will be excluded from study entry:

1. Greater than 50% tumor burden in the liver by imaging.

2. History of orthotopic liver transplantation, Whipple's procedure, hepatic vasculature incompatible with perfusion, hepatofugal flow in the portal vein or known unresolved venous shunting.

3. Evidence of ascites on imaging study, or the use of diuretics for ascites.

4. Clinically significant encephalopathy.

5. History of, or known, hypersensitivity to any components of melphalan or the components of the Melphalan/HDS system.

6. Known hypersensitivity to heparin or the presence of heparin-induced thrombocytopenia.

7. Received an investigational agent for any indication within 30 days prior to first treatment.

8. Not recovered from side effects of prior therapy to ≤ Grade 1 (according to National Cancer Institute [NCI] CTCAE version 4.03). Certain side effects that are unlikely to develop into serious or life-threatening events (e.g. alopecia) are allowed at > Grade 1.

9. Those with New York Heart Association functional classification II, III or IV; active cardiac conditions including unstable coronary syndromes (unstable or severe angina, recent myocardial infarction), worsening or new-onset congestive heart failure, significant arrhythmias and severe valvular disease must be evaluated for risks of undergoing general anesthesia.

10. History or evidence of clinically significant pulmonary disease that precludes the use of general anesthesia.

11. Uncontrolled diabetes mellitus, hypothyroidism, or hyperthyroidism.

12. Active infection, including Hepatitis B and Hepatitis C infection. Patients with anti-hepatitis B core antigen (HBc) positive, or hepatitis B surface antigen (HBsAg) but viral deoxyribonucleic acid (DNA) negative are exception(s).

13. History of bleeding disorders.

14. Brain lesions with a propensity to bleed.

15. Known varices at risk of bleeding, including medium or large esophageal or gastric varices, or active peptic ulcer.

16. Previous malignancy within 3 years prior to enrollment, except for curatively-treated basal cell or squamous cell carcinoma of the skin, cervical carcinoma in situ, bladder carcinoma in situ or breast cancer in situ.

17. Inadequate hematologic function as evidenced by any of the following:

1. Platelets < 90,000/µL

2. Hemoglobin < 8 g/dL, independent of transfusion or growth factor support

3. Neutrophils < 1,500 cells/µL.

18. Serum creatinine > 1.5 mg/dL.

19. Inadequate liver function as evidenced by any of the following:

1. Total serum bilirubin ≥ 2.0 mg/dL

2. Prothrombin time (PT)/international normalized ratio (INR) > 1.5

3. Aspartate aminotransferase (AST) > 10 times the upper limit of normal (ULN) or alanine aminotransferase (ALT) > 5 times ULN

4. Serum albumin < 3.0 g/dL.

20. Known alcohol abuse.

21. For female subjects of childbearing potential (i.e., have had a menstrual period within the past 12 months): a positive serum pregnancy test (β-human chorionic gonadotropin [β HCG]) within 7 days prior to enrollment; or unwilling or unable to undergo hormonal suppression to avoid menstruation during treatment.

22. Sexually active females of childbearing potential and sexually active males with partners of reproductive potential: unwilling or unable to use appropriate contraception from screening until at least 30 days after last administration of study treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Delcath Systems Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Johnny John, MD

Role: STUDY_DIRECTOR

Delcath Systems

Locations

Universitätsklinikum Frankfurt

Frankfurt, , Germany

Medizinische Hochschule Hannover

Hanover, , Germany

Universitätsklinikum Jena

Jena, , Germany

Countries

Germany

Other Identifiers

PHP-HCC-202

Identifier Type: -

Identifier Source: org_study_id