Attention and Social Behavior in Children

NCT ID: NCT02401282

Last Updated: 2018-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

251 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2016-12-17

Brief Summary

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This study examines the way attention may be linked to temperamental risk for anxiety, social behavior and brain processes. The study aims to see if temperamentally at risk youth display an attention bias towards threat, and if anxiety symptoms can be reduced through attentional bias modification training.

Detailed Description

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Conditions

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Anxiety

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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ABM

Attention bias modification

Group Type EXPERIMENTAL

Attention Bias Modification

Intervention Type BEHAVIORAL

This is a modification of the dot-probe task (placebo task) designed to train attention away from threat

Placebo

Dot-probe task

Group Type PLACEBO_COMPARATOR

Dot-probe task

Intervention Type BEHAVIORAL

This is the active control placebo condition that simply measures levels of attention to threat

Interventions

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Attention Bias Modification

This is a modification of the dot-probe task (placebo task) designed to train attention away from threat

Intervention Type BEHAVIORAL

Dot-probe task

This is the active control placebo condition that simply measures levels of attention to threat

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 9-12 year olds who do not meet exclusionary criteria (split into groups based on high and low temperamental shyness)

Exclusion Criteria

* presence or permanent metal orthodontics or implanted metal devices
* severe psychiatric diagnosis
* IQ under 70 as assessed by the WISC
Minimum Eligible Age

9 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

Penn State University

OTHER

Sponsor Role lead

Responsible Party

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Koraly E. Perez-Edgar

Associate Professor of Psychology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Penn State University Child Study Center

University Park, Pennsylvania, United States

Site Status

Countries

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United States

References

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LoBue V, Perez-Edgar K. Sensitivity to social and non-social threats in temperamentally shy children at-risk for anxiety. Dev Sci. 2014 Mar;17(2):239-47. doi: 10.1111/desc.12110. Epub 2013 Nov 28.

Reference Type BACKGROUND
PMID: 24283271 (View on PubMed)

McDermott JM, Perez-Edgar K, Henderson HA, Chronis-Tuscano A, Pine DS, Fox NA. A history of childhood behavioral inhibition and enhanced response monitoring in adolescence are linked to clinical anxiety. Biol Psychiatry. 2009 Mar 1;65(5):445-8. doi: 10.1016/j.biopsych.2008.10.043. Epub 2008 Dec 24.

Reference Type BACKGROUND
PMID: 19108817 (View on PubMed)

Perez-Edgar K, McDermott JN, Korelitz K, Degnan KA, Curby TW, Pine DS, Fox NA. Patterns of sustained attention in infancy shape the developmental trajectory of social behavior from toddlerhood through adolescence. Dev Psychol. 2010 Nov;46(6):1723-30. doi: 10.1037/a0021064.

Reference Type BACKGROUND
PMID: 20873921 (View on PubMed)

Perez-Edgar K, Reeb-Sutherland BC, McDermott JM, White LK, Henderson HA, Degnan KA, Hane AA, Pine DS, Fox NA. Attention biases to threat link behavioral inhibition to social withdrawal over time in very young children. J Abnorm Child Psychol. 2011 Aug;39(6):885-95. doi: 10.1007/s10802-011-9495-5.

Reference Type BACKGROUND
PMID: 21318555 (View on PubMed)

Perez-Edgar K, Roberson-Nay R, Hardin MG, Poeth K, Guyer AE, Nelson EE, McClure EB, Henderson HA, Fox NA, Pine DS, Ernst M. Attention alters neural responses to evocative faces in behaviorally inhibited adolescents. Neuroimage. 2007 May 1;35(4):1538-46. doi: 10.1016/j.neuroimage.2007.02.006. Epub 2007 Feb 15.

Reference Type BACKGROUND
PMID: 17376704 (View on PubMed)

Williams LR, Degnan KA, Perez-Edgar KE, Henderson HA, Rubin KH, Pine DS, Steinberg L, Fox NA. Impact of behavioral inhibition and parenting style on internalizing and externalizing problems from early childhood through adolescence. J Abnorm Child Psychol. 2009 Nov;37(8):1063-75. doi: 10.1007/s10802-009-9331-3.

Reference Type BACKGROUND
PMID: 19521761 (View on PubMed)

Liu P, Taber-Thomas BC, Fu X, Perez-Edgar KE. Biobehavioral Markers of Attention Bias Modification in Temperamental Risk for Anxiety: A Randomized Control Trial. J Am Acad Child Adolesc Psychiatry. 2018 Feb;57(2):103-110. doi: 10.1016/j.jaac.2017.11.016. Epub 2017 Nov 28.

Reference Type DERIVED
PMID: 29413142 (View on PubMed)

Other Identifiers

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5R01MH094633-04

Identifier Type: NIH

Identifier Source: secondary_id

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5R01MH094633-04

Identifier Type: NIH

Identifier Source: org_study_id

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