Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application

NCT ID: NCT02386163

Last Updated: 2015-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2015-08-31

Brief Summary

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According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.

Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of TKR (Total Knee Replacement). The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare their characterization and potential for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)".

Detailed Description

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Conditions

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Knee Injuries

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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MSC from synovial membrane and infrapatellar Fat Pad

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

Patient who have an total knee replacement surgery

Exclusion Criteria

Patient who don't sign the agreement
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Far Eastern Memorial Hospital

OTHER

Sponsor Role collaborator

EMO Biomedicine Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chih-Hung Chang, MD, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Far Eastern Memorial Hospital

Shing-Mou Lee

Role: STUDY_CHAIR

EMO Biomedicine Corp.

Locations

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Far Eastern Memorial Hospital

New Taipei City, Taiwan, Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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EMO-IF-MSC-01

Identifier Type: -

Identifier Source: org_study_id

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