The Predictive Value of CT-PET in Esophageal Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2016-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A major focus of research in oncology is to identify patients who, following induction therapy, have a complete pathologic response, presenting opportunities for novel trials, including extended therapy or non-operative approaches, in addition to identifying cohorts who are resistant to the neoadjuvant therapy. The current gold standard for determining response to CRT is pathological evaluation following surgical resection, in particular the Mandard Tumour Regression Grade (TRG) or some modification thereof. At this time, however, there is no preclinical early response or post-treatment biomarker, nor endoscopic or radiologic assessment that predicts pathologic response prior to surgical resection.The aim of this study is to determine the accuracy of CT-PET for prediction of histopathologic response and/or oncologic outcome for patients with esophageal cancer.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Early Metabolic Response in Locally Advanced Esophageal Cancer Undergoing Induction Chemoradiotherapy

NCT01269970

Esophageal Carcinoma (Squamous Cell Carcinoma - Adenocarcinoma)

COMPLETED

The Role of PET/MRI in Predicting the Outcome of Definitive Chemoradiotherapy for Esophageal Cancer Patients

NCT05855278

Esophageal Cancer

COMPLETED NA

PET-CT Based Radiotherapy in Esophageal Cancer Patients

NCT01156831

Esophageal Neoplasms

COMPLETED

Prediction of Lymphatic Metastasis in Esophageal Cancer by CT Radiomics

NCT03237130

Esophagus Cancer

COMPLETED

MR/PET in the Evaluation of Patients With Esophageal Cancer

NCT02547610

Esophageal Cancer

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Esophageal Neoplasms

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Locally advanced esophageal or junctional neoplasm
* Histologically confirmed adenocarcinoma or squamous cell carcinoma
* Scheduled to undergo nCRT followed by surgery as per multidisciplinary Tumor Board
* CT-PET at diagnosis of malignancy (within 2 weeks from diagnosis), performed at study Center
* CT-PET 4-6 weeks after completion of nCRT, prior to surgical resection