Molecular Mechanism of Neutrophil Necroptosis and Its Roles in RA Pathogenesis
NCT ID: NCT02385331
Last Updated: 2015-03-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
30 participants
OBSERVATIONAL
2015-03-31
2016-02-29
Brief Summary
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Detailed Description
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In this project, the investigators aim to investigate the mechanisms and the effects ofneutrophil necroptosis and apoptosis: 1. to investigate the cells and the molecular mechanisms that induce neutrophil necroptosis or delay apoptosis, mainly focusing on the roles of HMGB-1,TNF-α and LPS, 2. to illustrate the effects of some molecules such as TLR, TNFR, RIP1/RIP3, Caspase8, ATP and ROS in the process of sigal transduction and membrane damage during necroptosis or apoptosis , 3. to identify the similarities and differences between traditional necrosis and necroptosis in the aspects of morphologigical changes and inflammatory cytokine release, 4. to find out the effects and mechanisms of neutrophil necroptosis or apoptosis in a rheumatoid arthritis mouse model and the therapeutic effect of blocking one or several pathways in the pathogenesis of rheumatoid arthritis.
This study will not only unravel the mechanisms of neutrophil necroptosis and apoptosis, elucidate its roles and significances in inflammation and infection, but also shed new light on anti-inflammatory and anti-infection therapy.
Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
* age 18-65.
Exclusion Criteria
18 Years
65 Years
ALL
Yes
Sponsors
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The Third Affiliated Hospital of Southern Medical University
OTHER_GOV
Responsible Party
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Hongyu Jie
Dr. Hongyu,Jie
Principal Investigators
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ew Sun, doctor
Role: STUDY_DIRECTOR
Third Affiliated Hospital of Southern Medical University
Locations
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Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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201501004
Identifier Type: -
Identifier Source: org_study_id
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