Thromboelastography and Pancreas-kidney Transplantation

NCT ID: NCT02385006

Last Updated: 2015-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

152 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2014-11-30

Brief Summary

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Type of study:Prospective, single-center, non-therapeutic, of routine care No randomization, no modifications of the usual care, study results are not available for the physicians in charge of the patient.

Objectives:

* The main objective of this study is to evaluate the ability of the thromboelastogram (ROTEM®) to detect clotting disorders related to pancreas-kidney transplantation, comparing ROTEM ® profiles during the perioperative period of two different types of transplantation (kidney alone and simultaneous pancreas-kidney)
* The secondary objectives are:

1. To assess the incidence and type of coagulation disorders during the perioperative period of these two types of transplantation
2. To study correlation values between thrombolelastogram and standard coagulation parameters

Population study:

* Evaluated group: 40 pancreas-kidney recipients
* Control group: 80 kidney recipients
* Recruitment periods: 24 months
* Patient Monitoring: 48 hours
* Total duration of the study: 36 months.
* Ethics: Study of routine care. Oral and written information given to patients. Validation of the study protocol by the local ethics committee (CPP Sud Est II: Protocol No. HCL / P 2012.727)

Detailed Description

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Conditions

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Blood Coagulation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Arm kidney transplanted

Arm kidney transplanted: all patients who receive kidney transplantation

Group Type OTHER

Blood sample

Intervention Type BIOLOGICAL

Arm pancreas-kidney transplanted

Arm pancreas-kidney transplanted: all patients who receive pancreas-kidney transplantation

Group Type OTHER

Blood sample

Intervention Type BIOLOGICAL

Interventions

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Blood sample

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Men, women \> 18 years old
* Kidney or pancreas-kidney recipients
* Not opposed to research
* With no legal protection
* Affiliated to social security system

Exclusion Criteria

-Enrollment in an other research protocol, incompatible with the trial according to the investigator
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Anesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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2012.727

Identifier Type: -

Identifier Source: org_study_id

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