Characterization of Methylation Patterns in Lung Cancer

NCT ID: NCT02373917

Last Updated: 2021-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

683 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2021-04-30

Brief Summary

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In this study the investigators will collect Blood,sputum and saliva samples for Characterization of Methylation Patterns in lung Cancer.

Detailed Description

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Lots of information about the relationship between changes in methylation patterns and various diseases are accumulated in recent years. Characterization of methylation changes that occur in cancer may contribute to the development of methods for early detection of cancer by detecting cancer cells in liquids. Early detection of such changes and their correlation examining different cancers may lead to a diagnostic tool for the early detection of cancers and improve the treatment of these patients. Detection by molecular analysis can be a sensitive method and non-invasive early diagnosis of the disease In this study the investigators will collect Blood,sputum and saliva samples for Characterization of Methylation Patterns in lung Cancer.

Conditions

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Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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study group

patient who in the biopsy showed lung cancer

No interventions assigned to this group

control group

patient who in the biopsy showed not to have lung cancer

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with suspected lung tumor

Exclusion Criteria

* Patients who have active disease other than lung cancer during the sample collecting
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nucleix Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eilon Ganor, MD

Role: STUDY_DIRECTOR

Nucleix Ltd.

Locations

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Sha'are Tzedaek Medical Center

Jerusalem, , Israel

Site Status

Countries

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Israel

References

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Gaga M, Chorostowska-Wynimko J, Horvath I, Tammemagi MC, Shitrit D, Eisenberg VH, Liang H, Stav D, Levy Faber D, Jansen M, Raviv Y, Panagoulias V, Rudzinski P, Izbicki G, Ronen O, Goldhaber A, Moalem R, Arber N, Haas I, Zhou Q. Validation of Lung EpiCheck, a novel methylation-based blood assay, for the detection of lung cancer in European and Chinese high-risk individuals. Eur Respir J. 2021 Jan 14;57(1):2002682. doi: 10.1183/13993003.02682-2020. Print 2021 Jan.

Reference Type DERIVED
PMID: 33122336 (View on PubMed)

Other Identifiers

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Lung-RND-001

Identifier Type: -

Identifier Source: org_study_id

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