REMUNE + AMPLIVAX IR103 HIV/AIDS Phase III Safety & Efficacy Study

NCT ID: NCT02366026

Last Updated: 2016-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-30

Study Completion Date

2019-06-30

Brief Summary

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The primary objective is to compare \& evaluate between the treatment groups the changes in decline/reduction of HIV viral load changes in the Remune + Amplivax group vs the Amplivax placebo groups. Additional objectives include changes in WBC White Blood Cell counts \& CD4+ \& CD8+ T cell counts along with increased HIV immunity.

Detailed Description

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This is a 500 subject Multi Center double-blind randomized, Safety \& Efficacy, HIV/AIDS Phase III study, to primarily to evaluate the safety and efficacy of HIV-1 immunogen \& Amplivax compared to placebo group Amplivax in viral load, and secondarily to examine changes in CD4+ \& CD8+ T cell counts, determine Remune vaccines effect of multiple inoculations of HIV-1 immunogen + Amplivax on viral replication in adults with HIV-1 infection \& to examine immunogenicity of Remune + Amplivax in a Multi-center, randomized , double-blind, placebo-controlled, two arm parallel design study of Remune + Amplivax.

Conditions

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HIV

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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IR103 REMUNE + AMPLIVAX 1.0

IR103 Vaccine contain the same active component as REMUNE® (Inactivated HIV-1 Antigen Drug Substance at 10 μg/mL p24 dose), and have one dose of Amplivax™ (HYB2055) Adjuvant (1.0 mg) added before emulsification in Incomplete Freund's Adjuvant (the same adjuvant and in the same ratio that is used in REMUNE).

Group Type EXPERIMENTAL

IR103

Intervention Type BIOLOGICAL

REMUNE HIV/AIDS Vaccine with two adjuvants IFA + Amplivax

AMPLIVAX 1.0 + IFA

AMPLIVAX 1.0 mg Amplivax™ (HYB2055) Adjuvant (1.0 mg) + IFA Incomplete Freund's Adjuvant (the same adjuvant and in the same ratio that is used in REMUNE).

Group Type PLACEBO_COMPARATOR

IR103

Intervention Type BIOLOGICAL

REMUNE HIV/AIDS Vaccine with two adjuvants IFA + Amplivax

Interventions

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IR103

REMUNE HIV/AIDS Vaccine with two adjuvants IFA + Amplivax

Intervention Type BIOLOGICAL

Other Intervention Names

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HIV-1 IMMUNOGEN + Amplivax REMUNE + Amplivax

Eligibility Criteria

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Inclusion Criteria

* Are HIV-positive and started anti-HIV drugs soon after tests showed the presence of HIV.
* Are at least 16 years old (consent of parent or guardian required if under 18 years).

Exclusion Criteria

* Healthy Subjects
* Currently abuse alcohol or drugs.
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Immune Response BioPharma, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard Bartholomew, PhD

Role: STUDY_DIRECTOR

Immune Response BioPharma, Inc.

Locations

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Clinical Site TBA

San Diego, California, United States

Site Status

Countries

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United States

Central Contacts

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Richard Bartholomew, PhD.

Role: CONTACT

858-414-4664

Facility Contacts

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Richard Bartholomew, PhD

Role: primary

858-414-4664

Related Links

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http://www.immuneresponse.net

Immune Response BioPharma, Inc.

Other Identifiers

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IR103-007

Identifier Type: -

Identifier Source: org_study_id

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