PET-CT After Nellix Implantation

NCT ID: NCT02349100

Last Updated: 2017-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-31

Study Completion Date

2016-08-30

Brief Summary

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To determine FDG uptake following uncomplicated EVAR using the Nellix endoprosthesis. Does uncomplicated EVAR using the nellix endoprosthesis result in increased FDG uptake and false positive PET imaging?

Detailed Description

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One of the most devastating complications following endovascular aneurysm repair (EVAR) is infection of the used endoprosthesis. Because of the high mortality of secondary surgery following infection, patients with a possible endoprosthesis infection are treated using broadspectrum antibiotics during months, years or even life-long. Unfortunately, the diagnosis of an endoprosthesis infection is difficult and based upon clinical suspicion and non-specific symptoms (e.g. fever and weigth loss) only. Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is often used as a diagnostic tool to identify infection following EVAR. Like infection, sterile physiologic inflammation following EVAR is also associated with increased metabolism and FDG uptake. This could result in (false-)positive PET imaging resulting in diagnostic errors and antibiotic overuse.

The Nellix endoprosthesis is a relatively new device used for EVAR. In present literature there is no data on the degree of physiologic inflammation following implantation of a Nellix device and the value of postoperative FDG-PET imaging to detect infection is not known. This makes the diagnosis of infection following Nellix implantation extremely difficult. This pilot is designed to determine physiologic FDG uptake following uncomplicated EVAR using the Nellix endoprosthesis.

Conditions

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Aortic Aneurysm Endovascular Repair

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Treated group

Patient group treated with Nellix Endoprosthesis.

Nellix Endoprosthesis

Intervention Type DEVICE

Implantation of Nellix

Interventions

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Nellix Endoprosthesis

Implantation of Nellix

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients treated with Nellix endoprosthesis

Exclusion Criteria

* Diabetes Mellitus (Type 1 and type 2)
* Current known inflammation or malignancy
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rijnstate Hospital

OTHER

Sponsor Role lead

Responsible Party

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Michel Reijnen

M.D., PhD.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michel Reijnen, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Rijnstate Hospital

Locations

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Rijnstate Ziekenhuis

Arnhem, Gelderland, Netherlands

Site Status

Countries

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Netherlands

References

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Groot Jebbink E, van Den Ham LH, van Woudenberg BBJ, Slart RHJA, Zeebregts CJ, Rijnders TJM, Lardenoije JHP, Reijnen MMPJ. Physiological Appearance of Hybrid FDG-Positron Emission Tomography/Computed Tomography Imaging Following Uncomplicated Endovascular Aneurysm Sealing Using the Nellix Endoprosthesis. J Endovasc Ther. 2020 Jun;27(3):509-515. doi: 10.1177/1526602820913888. Epub 2020 Apr 15.

Reference Type DERIVED
PMID: 32295455 (View on PubMed)

Other Identifiers

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1093

Identifier Type: -

Identifier Source: org_study_id

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