Detection of Chlamydia DNA by Polymerase Chain Reaction in Primary Tubal and Ovarian Cancers Tissues : a Pilot Study

NCT ID: NCT02343510

Last Updated: 2017-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-31

Study Completion Date

2017-03-31

Brief Summary

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PCR for chlamydia DNA is done in paraffin blocks of cases of primary tubal cancer and is compared to cases of high grade serous ovarian cancer and normal tubes .

Detailed Description

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The investigators shall review the early cancer detection unite pathology records for the past 10 years , for cases diagnosed with primary Fallopian tube cancers , cases of high and low grade serous ovarian cancer and cases underwent hysterectomy and salpingectomy for non oncological reasons. Paraffin blocks for suitable selected patients will be examined histologically to confirm the primary diagnosis . Chlamydia DNA in these paraffin blocks of the Fallopian tubes and ovarian tissues will be examined using PCR techniques . The possible correlation between the presence of Chlamydia DNA and the ovarian serous tumours and primary tubal cancer will be analyzed statistically .

Conditions

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Malignant Neoplasm of Fallopian Tube

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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primary tubal cancer group

Paraffin blocks of cases of primary tubal cancer

PCR for chlamydia DNA in primary tubal cancer

Intervention Type OTHER

PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

high grade serous ovarian cancer group

Paraffin blocks of cases of high grade serous ovarian cancer

PCR for chlamydia DNA in primary tubal cancer

Intervention Type OTHER

PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

Low Grade Serous Ovarian Cancer

Paraffin blocks of cases of low grade serous ovarian cancer

PCR for chlamydia DNA in primary tubal cancer

Intervention Type OTHER

PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

normal tubes group

Paraffin blocks of tubes of hysterectomies due to non-oncologic causes

PCR for chlamydia DNA in primary tubal cancer

Intervention Type OTHER

PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

Interventions

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PCR for chlamydia DNA in primary tubal cancer

PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* any patient with primary tubal cancer and high grade serous cancer and normal tubes.

Exclusion Criteria

* clinical pelvic inflammatory disease
* salpingectomy for ectopic
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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dr mohamed laban

professor mohammed laban

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ain Shams Maternity Hospital

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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lab7682

Identifier Type: -

Identifier Source: org_study_id

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