Cardiometabolic Response to Sit-stand Workstations.

NCT ID: NCT02342301

Last Updated: 2016-05-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-09-30
• Study Completion Date: 2015-09-30

Brief Summary

We aim to determine if changing a person's workstation from a traditional seated desk to a height adjustable "standing desk" for a period of approximately 3 months is associated with alterations in traditional measures of cardiometabolic risk.

Detailed Description

The present study will include 24 male and female participants 18 years of age and older who work in an office-based setting. To be included participants must be abdominally obese, defined as a waist circumference ≥ 88 cm for women, and 102 cm for men. All potential participants will be asked to come to the Human Performance Laboratory at University of Prince Edward Island and will be given an opportunity to ask questions about the study, and to read and sign the informed consent form. Once this has taken place, participants will have their waist circumference measured in order to determine whether they meet the above criteria. If not, the individual will be thanked for their time and told that they are not eligible to participate in the current study.

Lab Day 1 (baseline)

Once screening is complete, participants will have glycosylated hemoglobin checked via a simple finger prick and point-of-care analysis of a single drop of blood. (Funding dependent, a second drop of blood may be used to analyze the participant's blood lipid profile- as would be done at a typical doctor's office visit). Next we will measure the participants' resting metabolic rate, by having them lay on a hospital bed while we analyze the oxygen and carbon dioxide concentrations of the air they exhale. This will inform us as to the participant's baseline caloric needs. Blood pressure, height, weight, waist circumference and body composition will be determined following resting metabolic rate, prior to the determination of aerobic fitness using a sub-maximal exercise protocol (see below).

Augmentation Index:

Arterial stiffness will be determined using a Sphygmocor pulse wave applanation tonomoter (Atcor Medical). This device measures arterial pulse waves non-invasively through the skin at the wrist. We will use this same device to analyze the shape of the pulse wave, which will give us information about reflected pulse waves (and thus the stiffness of the arterial tree). The measure of arterial stiffness is non-invasive and pain-free and is taken using a pen-like tool pressed against the participant's skin to detect his or her pulse.

Prior to departing the lab, participants will be instructed on the use of an accelerometer-based activity monitor (20 min), which they will wear for 1 week prior to the desk intervention. During the activity monitor collection week, participants will also be instructed to wear a heart rate belt (non-invasive chest strap) for one day during working hours only (at least 4 hours of data collection) which will be analyzed after the strap is returned to the lab. Participants will then answer an online questionnaire about his/her current physical activity and sedentary behaviors. https://docs.google.com/forms/d/1fjz5ua47KzcdnhCAN7wCDGNbvy-tKSGgZKGGhIKSqQg/viewform?usp=mail_form_link . A similar questionnaire will be used for post- intervention follow-up with the tenses changed and questions about "anticipated" desk use altered to report on "actual" use (participants in the control group will be asked to answer "not applicable" for any questions related to standing desk use on the follow-up questionnaire).

Total participation Time (1.5 hr)

Once the baseline testing session is complete, participants will be randomly allocated to intervention or control groups (12 participants per group). Participants in the intervention group will be asked to complete the below intervention, while those in the control group will be asked to maintain their current lifestyle and office workstation throughout the study.

Intervention- the participant will be given a stand-up desk and asked to use it in place of their normal desk at work. Participants will again be given the activity and HR monitors to wear during the first and last 2 weeks of desk use.

Lab day 2 (post) - all measures from lab day 1 will be repeated as described above.

Aerobic Fitness- Aerobic fitness will be determined using a treadmill-based graded exercise test with analysis of expired gases. The test will consist of 2-3 increasingly more challenging stages of walking/running (through the addition of speed or incline) at a submaximal intensity. The heart rate and oxygen consumption data collected will be used to extrapolate the data to estimate maximal values. All aerobic fitness tests will be administered under the supervision of a Canadian Society for Exercise Physiology Certified Exercise Physiologist. Prior to any exercise all participants will be required to complete a Physical Activity Readiness Questionnaire (PAR-Q+) safe exercise participation screening form for known or suspected chronic disease risk factors (this tool is used for screening purposes only).

Resting metabolic rate will be determined using the same electrochemical analyzers (on the same metabolic cart) as the exercise measures, except a different flowmeter and gas collection system will be used (namely, we will use a canopy rather than a face mask). This will allow the participant to relax and rest normally without the need of having their nose and mouth covered by a rubber mask, as their entire head and shoulders will be contained within a canopy to collect gases. This system is identical to those used in-hospital.

Conditions

Sedentary Lifestyle

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Standing Desk

Will use standing desk for 3 months

Group Type: EXPERIMENTAL

Standing Desk

Intervention Type: BEHAVIORAL

Participants will be provided with a standing desk for 3 months

Traditional Desk

Will use traditional desk for 3 months

Group Type: ACTIVE_COMPARATOR

Traditional Desk

Intervention Type: BEHAVIORAL

Participants will use a traditional seated desk for 3 months

Interventions

Standing Desk

Participants will be provided with a standing desk for 3 months

Intervention Type: BEHAVIORAL

Traditional Desk

Participants will use a traditional seated desk for 3 months

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• male and female participants
• 18 years of age and older
• work in an office-based setting.
• abdominally obese, defined as a waist circumference ≥ 88 cm for women, and 102 cm for men.

Exclusion Criteria

• glucose lowering medication
• inability to stand or walk

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Prince Edward Island

OTHER

Sponsor Role: lead

Responsible Party

Travis Saunders

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jamie Burr, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Prince Edward Island

Locations

Human Performance and Health Research Lab, University of Prince Edward Island

Charlottetown, Prince Edward Island, Canada

Countries

Canada

Other Identifiers

6005871

Identifier Type: -

Identifier Source: org_study_id