Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma
NCT ID: NCT02327234
Last Updated: 2016-04-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
13 participants
INTERVENTIONAL
2014-12-31
2015-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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Ibuprofen
400mg (2X200mg) ibuprofen single dose once
ibuprofen
2x 200mg ibuprofen, single dose, blinded in 00 capsules
Placebo
identical appearing lactose capsules single dose 2 capsules once
Placebo
lactose filled 00 capsules to match appearance of ibuprofen intervention
Interventions
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ibuprofen
2x 200mg ibuprofen, single dose, blinded in 00 capsules
Placebo
lactose filled 00 capsules to match appearance of ibuprofen intervention
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* has allergies that trigger asthma
* responds to methacholine challenge at 16mg/ml or less
* has FEV1 \> 69.5% predicted
Exclusion Criteria
* other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data
* pregnant or lactating females
* hypersensitivity to ibuprofen
18 Years
70 Years
ALL
No
Sponsors
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University of Saskatchewan
OTHER
Responsible Party
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Don Cockcroft
Professor
Principal Investigators
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Don Cockcroft, MD
Role: PRINCIPAL_INVESTIGATOR
University of Saskatchewan
Locations
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University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Countries
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References
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Nomani S, Cockcroft DW, Davis BE. Allergen inhalation challenge, refractoriness and the effects of ibuprofen. Allergy Asthma Clin Immunol. 2016 May 24;12:24. doi: 10.1186/s13223-016-0127-z. eCollection 2016.
Other Identifiers
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Bio REB 14-283
Identifier Type: -
Identifier Source: org_study_id
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