Whole-body Vibration as a Treatment for Parkinson's Disease
NCT ID: NCT02306863
Last Updated: 2015-02-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2015-01-31
2015-08-31
Brief Summary
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Detailed Description
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Whole-body vibration (WBV) is potentially beneficial in treating Parkinson's disease because it has been shown to elicit effects specific to both the brain and muscular system. Animal models of PD indicate that whole-body vibration can increase striatal dopamine levels, as well as the number of dopaminergic neurons in the substantia nigra. These findings were correlated with increased levels of brain-derived neurotrophic factor.
In addition to the potentially neuroplastic effects, \>20 Hz WBV has been shown to improve muscular performance. Improved muscular performance is believed to be attributed to WBV induced neuromuscular effects rather than muscle hypertrophy, with the specific mechanism defined as the tonic vibration reflex.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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whole-body vibration
40 Hz Whole-body vibration applied via physioaccoustic method for 12 weeks, 3 times a week
vibrating chair
vibration provided via physioacoustic method
sham treatment
simulated whole-body vibration applied 3 times a week for 12 weeks
sham treatment
simulated whole-body vibration
Interventions
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vibrating chair
vibration provided via physioacoustic method
sham treatment
simulated whole-body vibration
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Currently taking anti-Parkinsonian medication
* Able to stand for 2 minutes without assistance
* Able to walk 10 meters without assistance
* Ability to understand English instructions
* Normal or corrected vision
Exclusion Criteria
* recent stroke
* cardiovascular disease
* previous major hemorrhage
* artificial pacemaker
* currently pregnant
* Current participation in any physical therapy or experimental treatments
* Peripheral neuropathy, severe osteoporosis
* Visual impairments that cannot be corrected
* Clinically diagnosed with dementia
* Greater than mild dementia (screened using Montreal Cognitive Assessment (MOCA) \<24 being excluded)
18 Years
ALL
No
Sponsors
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Sun Life Financial Movement Disorders Research and Rehabilitation Centre
OTHER
Responsible Party
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Adam Koebel
Undergraduate Thesis Student
Principal Investigators
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Adam K Koebel, BSc
Role: PRINCIPAL_INVESTIGATOR
Wilfrid Laurier University
Locations
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Sun Life Financial Movement Disorders Research & Rehabilitation Centre
Waterloo, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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References
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Haas CT, Turbanski S, Kessler K, Schmidtbleicher D. The effects of random whole-body-vibration on motor symptoms in Parkinson's disease. NeuroRehabilitation. 2006;21(1):29-36.
Ebersbach G, Edler D, Kaufhold O, Wissel J. Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson's disease. Arch Phys Med Rehabil. 2008 Mar;89(3):399-403. doi: 10.1016/j.apmr.2007.09.031.
King LK, Almeida QJ, Ahonen H. Short-term effects of vibration therapy on motor impairments in Parkinson's disease. NeuroRehabilitation. 2009;25(4):297-306. doi: 10.3233/NRE-2009-0528.
Other Identifiers
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4291
Identifier Type: -
Identifier Source: org_study_id
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