The Effect of Vitamin B3 on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men
NCT ID: NCT02303483
Last Updated: 2017-07-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2016-01-04
2017-04-04
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Placebo
lime tablets
Placebo
Nicotinamide riboside (NR, Vit B3)
NIAGEN (ChromaDex) 1 g x 2 orally per day
Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA )
Interventions
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Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA )
Placebo
Eligibility Criteria
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Inclusion Criteria
* male
* BMI\>30 kg/(m2)
* age: 40-70
* no medication
* non-smoker
Exclusion Criteria
* other severe disease
* high daily activity level (\>30 min / day)
40 Years
70 Years
MALE
Yes
Sponsors
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University of Copenhagen
OTHER
Aarhus University Hospital
OTHER
Responsible Party
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Ole Dollerup
MD, PhD-student
Principal Investigators
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Ole Dollerup, MD
Role: PRINCIPAL_INVESTIGATOR
The Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Physiology, University of Copenhagen
Locations
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Medical Research Laboratories, Aarhus University Hospital
Aarhus, , Denmark
Countries
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References
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Dollerup OL, Chubanava S, Agerholm M, Sondergard SD, Altintas A, Moller AB, Hoyer KF, Ringgaard S, Stodkilde-Jorgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men. J Physiol. 2020 Feb;598(4):731-754. doi: 10.1113/JP278752. Epub 2019 Dec 26.
Dollerup OL, Trammell SAJ, Hartmann B, Holst JJ, Christensen B, Moller N, Gillum MP, Treebak JT, Jessen N. Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5703-5714. doi: 10.1210/jc.2019-01081.
Dollerup OL, Christensen B, Svart M, Schmidt MS, Sulek K, Ringgaard S, Stodkilde-Jorgensen H, Moller N, Brenner C, Treebak JT, Jessen N. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr. 2018 Aug 1;108(2):343-353. doi: 10.1093/ajcn/nqy132.
Other Identifiers
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44081
Identifier Type: -
Identifier Source: org_study_id
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