Speed of Processing Training to Improve Cognition in Multiple Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2020-02-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this research study is to investigate the effectiveness of a computerized technique designed to improve processing speed (i.e. the amount of time it takes for a person's brain to process information) in a multiple sclerosis (MS) population. The study is designed to study how well this technique can help people with MS increase their processing speed and their ability to function better in everyday life. This treatment protocol has been studied extensively with older adults, showing improvements on standard laboratory measures of processing speed and performance of activities of daily living.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Applying Speed of Processing Training to Individuals With Multiple Sclerosis

NCT01838824

Multiple Sclerosis

COMPLETED NA

Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment

NCT02020564

Traumatic Brain Injury Mild Cognitive Impairment

COMPLETED NA

Remote Exercise Effects on Cognitive Processing Speed in Multiple Sclerosis: A Pilot Trial

NCT05344040

Multiple Sclerosis

COMPLETED EARLY_PHASE1

Applying Speed of Processing Training to Individuals With Traumatic Brain Injury

NCT01838811

Traumatic Brain Injury

COMPLETED NA

Treating Cognitive Deficits in Traumatic Spinal Cord Injury (SCI)

NCT03985540

Spinal Cord Injuries

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study is a double-blind, placebo-control randomized clinical trial examining the efficacy of Speed of Processing Training (SPT) for improving processing speed (PS) deficits in persons with Multiple Sclerosis (MS). Slowed PS is one of the most common deficits in individuals with MS and such deficits have been shown to exert significant negative impact on multiple aspects of everyday life, including occupational and social functioning. Despite these findings, few studies have attempted to remediate PS deficits in order to improve the everyday functioning of individuals with MS. This study is designed to (1) apply a treatment protocol for PS impairments well-validated in an aging population to individuals with MS with objectively observable deficits in PS and document its efficacy on standard neuropsychological outcome measures. In addition, the investigators will (2) assess the effectiveness of the intervention utilizing global measures of everyday life, including an objective measure (the Timed Activities of Daily Living; TIADL), as well as additional questionnaires to be completed by both the participant and a significant other. This study is also designed to (3) examine the influence of degree of PS impairment on treatment efficacy using neuropsychological tests, (4) evaluate the long-term effects of the treatment protocol and (5) examine the utility of booster sessions to facilitate long-term treatment effects.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Multiple Sclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Speed of Processing Training (SPT)

SPT will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Group Type EXPERIMENTAL

Speed of Processing Training (SPT)

Intervention Type BEHAVIORAL

Placebo control group

Placebo control exercises will be administered on a laptop computer twice a week for 5 weeks (10 sessions)

Group Type PLACEBO_COMPARATOR

Placebo Control

Intervention Type BEHAVIORAL

Placebo control exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Speed of Processing Training (SPT)

Intervention Type BEHAVIORAL

Placebo Control

Placebo control exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* English as a primary language
* diagnosis of Multiple Sclerosis
* processing speed impairment (based on evaluation)

Exclusion Criteria

* most recent exacerbation within one month
* currently taking steroids or benzodiazepines
* history of significant psychiatric illness (bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder
* significant alcohol or drug abuse history

Minimum Eligible Age

18 Years

Maximum Eligible Age

59 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No