Biological Markers for the Diagnosis of Central Nervous System Infective Diseases

NCT ID: NCT02278016

Last Updated: 2016-01-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-31

Study Completion Date

2017-07-31

Brief Summary

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Bacterial meningitis is a potentially life-threatening disease that is associated with substantial neurological morbidity and mortality. Accurate diagnosis is essential to improve outcome and prevent antibiotic overuse. Here we try to explore new biological markers for the diagnosis of the central nervous system infection disease.

Detailed Description

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To investigate the diagnosis value of procalcitonin,interleukin-6, agiotensininâ…ˇin the cerebrospinal fluid in the central nervous system infection disease.

Conditions

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Infection

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Aged 13 years or older;
2. At least two of the following clinical characteristics:headache, fever, neck stiffness, mental symptoms or consciousness impairment or seizures
3. Patients' family signed informed consent.

Exclusion Criteria

1. Contraindications to lumbar puncture
2. Patients with active malignancy
Minimum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Xijing Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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jiang wen, MD

Role: STUDY_CHAIR

The Department of Neurology , Xijing Hospital

Locations

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Xijing Hospital

Xi'an, Shaanxi, China

Site Status RECRUITING

Countries

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China

Central Contacts

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jiang wen, MD

Role: CONTACT

029-84771319

Facility Contacts

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jiang wen, MD

Role: primary

029-84771319

References

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Li W, Sun X, Yuan F, Gao Q, Ma Y, Jiang Y, Yang X, Yang F, Ma L, Jiang W. Diagnostic Accuracy of Cerebrospinal Fluid Procalcitonin in Bacterial Meningitis Patients with Empiric Antibiotic Pretreatment. J Clin Microbiol. 2017 Apr;55(4):1193-1204. doi: 10.1128/JCM.02018-16. Epub 2017 Feb 8.

Reference Type DERIVED
PMID: 28179405 (View on PubMed)

Other Identifiers

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xijing-120

Identifier Type: -

Identifier Source: org_study_id

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