Healthy Start: Exploring the Fuel-mediated Programming of Neonatal Growth
NCT ID: NCT02273297
Last Updated: 2024-03-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
2821 participants
OBSERVATIONAL
2009-07-31
2026-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Pregnant women and their offspring
Ethnically diverse pregnant women and their offspring
Maternal factors
Interventions
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Maternal factors
Eligibility Criteria
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Inclusion Criteria
* Prior to 23 completed weeks of gestation
* Live in Colorado
Exclusion Criteria
* Preexisting
* cancer
* psychiatric disease
* steroid-dependent asthma, or
* diabetes
* Previous premature delivery prior to 25 weeks gestation or fetal demise
16 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
National Center for Advancing Translational Sciences (NCATS)
NIH
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Dana Dabelea, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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University of Colorado Denver
Aurora, Colorado, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Buck KE, Dhaliwal SK, Dabelea D, Perng W. Association of maternal psychosocial stress with newborn body composition in the Healthy Start study. J Dev Orig Health Dis. 2023 Oct;14(5):576-583. doi: 10.1017/S2040174423000223. Epub 2023 Sep 11.
Dhaliwal SK, Dabelea D, Lee-Winn AE, Crume T, Wilkening G, Perng W. Maternal psychosocial stress during pregnancy and offspring neurobehavioral outcomes during early childhood in the Healthy Start Study. Ann Epidemiol. 2023 Oct;86:16-24.e3. doi: 10.1016/j.annepidem.2023.06.001. Epub 2023 Jun 14.
Cohen CC, Harrall KK, Gilley SP, Perng W, Sauder KA, Scherzinger A, Shankar K, Sundaram SS, Glueck DH, Dabelea D. Body composition trajectories from birth to 5 years and hepatic fat in early childhood. Am J Clin Nutr. 2022 Oct 6;116(4):1010-1018. doi: 10.1093/ajcn/nqac168.
Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W. Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort. J Nutr. 2022 Mar 3;152(3):816-825. doi: 10.1093/jn/nxab403.
Moore BF, Sauder KA, Starling AP, Hebert JR, Shivappa N, Ringham BM, Glueck DH, Dabelea D. Proinflammatory Diets during Pregnancy and Neonatal Adiposity in the Healthy Start Study. J Pediatr. 2018 Apr;195:121-127.e2. doi: 10.1016/j.jpeds.2017.10.030. Epub 2017 Dec 6.
Perng W, Ringham BM, Glueck DH, Sauder KA, Starling AP, Belfort MB, Dabelea D. An observational cohort study of weight- and length-derived anthropometric indicators with body composition at birth and 5 mo: the Healthy Start study. Am J Clin Nutr. 2017 Aug;106(2):559-567. doi: 10.3945/ajcn.116.149617. Epub 2017 Jun 28.
Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar;65(3):647-59. doi: 10.2337/db15-0849. Epub 2015 Dec 2.
Starling AP, Brinton JT, Glueck DH, Shapiro AL, Harrod CS, Lynch AM, Siega-Riz AM, Dabelea D. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr. 2015 Feb;101(2):302-9. doi: 10.3945/ajcn.114.094946. Epub 2014 Dec 3.
Crume TL, Shapiro AL, Brinton JT, Glueck DH, Martinez M, Kohn M, Harrod C, Friedman JE, Dabelea D. Maternal fuels and metabolic measures during pregnancy and neonatal body composition: the healthy start study. J Clin Endocrinol Metab. 2015 Apr;100(4):1672-80. doi: 10.1210/jc.2014-2949. Epub 2015 Jan 9.
Other Identifiers
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