Effects of Propofol on Early Recovery of Hunger After Surgery
NCT ID: NCT02272166
Last Updated: 2017-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
116 participants
INTERVENTIONAL
2014-11-30
2016-07-31
Brief Summary
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The impact of anesthetics on hunger is largely unknown but few studies suggest an orexigenic effect of propofol compared to halogenated gases. These studies had neither the power nor the methodology to answer the question. The aim of our study is to evaluate the impact of propofol versus sevoflurane on early recovery of hunger after ambulatory surgery.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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propofol
Hypnotic used in this arm is exclusively intra-venous propofol.
propofol
sevoflurane
Hypnotic used in this arm is exclusively inhaled sevoflurane.
Sevoflurane
Interventions
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propofol
Sevoflurane
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) score 1-2
* Affiliated to a social security system
* Undergoing an ambulatory surgery during more than 15 minutes with general anesthesia and control of upper airways (tracheal intubation or supraglottic mask or facial mask ventilation) for oocytes punction before in vitro fertilization
* General anesthesia occuring between 8 and 10 am with respect of pre-operative fasting rules
* APFEL risk score for nausea and vomiting ≤ 2/4
* Ability to understand and read french
* Signature of understood consent
Exclusion Criteria
* Cognitive dysfunction
* Undernutrition or risk factor of undernutrition (evolutive neoplasia, chronic alcoholism …)
* BMI ≥ 35 kg/m²
* Eating disorders
* Diabetes mellitus
* Chronic treatment with drugs modifying feeding behavior :
* Benzodiazepines
* Inhibitors of serotonin reuptake
* Others
* Non respect of pre-operative fasting rules
* Indication for rapid sequence induction (gastro-oesophageal reflux, absence of gastric emptying …)
* Contraindication to propofol (allergia to propofol, soybean or peanuts, past history of propofol infusion syndrome, unstable cardiovascular disease) or to sevoflurane (past history of malignant hyperthermia, epilepsy or liver disorders after administration of a halogenated anesthetic)
* Pregnant or breastfeeding woman
* Involvement in another clinical trial under 4 previous weeks
18 Years
45 Years
FEMALE
No
Sponsors
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Centre Henri Becquerel
OTHER
University Hospital, Rouen
OTHER
Responsible Party
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Principal Investigators
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Bertrand Dureuil, MD-PHD
Role: STUDY_CHAIR
Departement of Anesthesia, University Hospital, Rouen
Emmanuel BESNIER, MD
Role: PRINCIPAL_INVESTIGATOR
Departement of Anesthesia, University Hospital, Rouen
Locations
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Rouen University Hospital
Rouen, , France
Countries
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References
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Besnier E, Perdrix A, Gillibert A, Selim J, Froemer B, Ghemired A, Berby B, Rives N, Dureuil B, Clavier T, Compere V. Postoperative hunger after outpatient surgery in patients anesthetized with propofol vs sevoflurane: a randomized-controlled trial. Can J Anaesth. 2020 May;67(5):550-559. doi: 10.1007/s12630-020-01584-w. Epub 2020 Jan 29.
Other Identifiers
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2014/088/HP
Identifier Type: -
Identifier Source: org_study_id