Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study

NCT ID: NCT02263638

Last Updated: 2019-03-12

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-02-04
• Study Completion Date: 2018-09-04

Brief Summary

Treatment of refractory hemochromatosis rheumatism by Anakinra. Prospective, multicenter, non-randomised, single-arm, open-label, phase II trial.

Detailed Description

Hereditary hemochromatosis (HH) is a genetic disease characterized by tissue iron overload. The most common genotype is homozygosity for the p.Cys282Tyr mutation of the HFE gene (MIM 235200). It is a serious disease which can lead to life threatening complications such as cirrhosis, liver carcinoma, heart failure or diabetes mellitus. Currently, these complications can be prevented by phlebotomies. Two-thirds of patients complain of joint symptoms which represent a major cause of impaired quality of life. Phlebotomies are ineffective on HH rheumatism and patients' quality of life is very often altered while life threatening complications are prevented. Furthermore, there is a significant higher risk for joint replacement surgery in these patients compared to controls (X 9). There is currently no approved treatment for hemochromatosis rheumatism. As it looks like severe osteoarthritis, calcium pyrophosphate deposition disease (CPDD) or chondrocalcinosis, symptomatic treatments are employed such as analgesics (type I or II), non-steroidal anti-inflammatory drugs or colchicine in case of acute joint flare, corticosteroids intra-articular injections or occasionally oral glucocorticoids. However in some cases these treatments remain ineffective leading to a true disability.

Frequently, there are local inflammatory symptoms. Interleukin 1ß (IL1ß) plays a key role in the pathogenesis of crystal arthropathies (CPDD or gout).

Anakinra (IL-1Ra), a drug approved in France for rheumatoid arthritis, has been tested in short series or case controls in refractory gout, CPDD and only in two patients with HH rheumatism. The aim of this phase II study is to test the efficacy of anakinra in patients with hemochromatosis and refractory joint pain. It is also to evaluate the opportunity to perform a phase III trial. In the absence of available data on the evolution of this rheumatism treated by anakinra in this population of patients resistant to standard therapy, the investigators consider that a phase III trial would not be justifiable if the rate of success is insufficient.

Conditions

Refractory Hemochromatosis Rheumatism

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Anakinra

One daily subcutaneous injection of a fixed dose of 100 mg will be administered at a fixed time by a nurse during a five day period

Group Type: EXPERIMENTAL

Anakinra

Intervention Type: DRUG

One daily subcutaneous injection of a fixed dose of 100 mg will be administered at a fixed time during a five day period

Interventions

Anakinra

One daily subcutaneous injection of a fixed dose of 100 mg will be administered at a fixed time during a five day period

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients with age equal to or over 18 years old,
• Patients with proved hereditary hemochromatosis with homozygosity for the C282Y mutation of the HFE gene,
• Patients with rheumatism related to hemochromatosis, considered by the rheumatologist refractory to usual treatment defined by a persistent painful symptomatology despite a treatment of at least one month with level 2 analgesics (weak opioids) at maximal dose, NSAID, colchicine, steroid injection or a combination of these treatments,
• Patients with pain > 40/100mm measured by VAS (pain of the last 48 hours),
• Effective contraception to be used during treatment and until 48h after the last administration for women of reproductive age,
• Patients who have given written informed consent.

Exclusion Criteria

• Other cause of inflammatory rheumatisms such as Rheumatoid Arthritis, Spondyloarthropathies, psoriatic arthritis, or systemic diseases,
• Ongoing treatment with Methotrexate, Hydroxychloroquine, biologic or immunosuppressive drugs
• Malignant pathology, monoclonal gammopathy,
• Intolerance to anakinra,
• Contraindications to the use of anakinra: pregnancy or breastfeeding, hypersensitivity to any of the excipients or to proteins from E. coli, severe renal impairment (creatinine clearance <30 ml / minute), neutropenia (neutrophil count <1.5 x 109 / l), ongoing infection
• Patients that cannot follow the protocol,
• Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Rennes University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pascal Richette

Role: PRINCIPAL_INVESTIGATOR

Groupe Hospitalier Lariboisière - Paris

Pascal Guggenbuhl

Role: PRINCIPAL_INVESTIGATOR

Rennes University Hospital

Locations

CHRU de Lille

Lille, , France

Groupe Hospitalier Lariboisière

Paris, , France

Rennes University Hospital

Rennes, , France

Countries

France

Other Identifiers

35RC13_8811_THERA

Identifier Type: OTHER

Identifier Source: secondary_id

2014-000609-10

Identifier Type: -

Identifier Source: org_study_id