Florida Neonatal Neurologic Network

NCT ID: NCT02260271

Last Updated: 2025-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-09-30

Study Completion Date

2025-12-31

Brief Summary

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Create a database with selected medical information on infants born with hypoxic-ischemic encephalopathy (HIE). In addition, the following samples will be collected in a bio-repository for future studies: blood, urine, and buccal samples.

Detailed Description

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The purpose of this study is to create a detailed medical and sample database of infants born with HIE. Both the medical information and the samples are de-identified. Any future studies performed with the data and samples will receive Institutional Review Board (IRB) approval.

Conditions

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Hypoxic-Ischemic Encephalopathy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Database Entry/Biospecimen Collection

Medical information of infants born with HIE entered into RedCap database. In addition, Blood, urine, buccal samples will be collected.

Database Entry/Biospecimen Collection

Intervention Type OTHER

blood, urine, buccal samples and medical data collected

Interventions

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Database Entry/Biospecimen Collection

blood, urine, buccal samples and medical data collected

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Gestational Age greater than or equal to 35 weeks gestation
* Birth weight greater than or equal to 1.8 kg
* Less than or equal to 6 hours since insult occurred
* Severe hypoxic-ischemic encepholopathy (HIE)

Exclusion Criteria

* Presence of lethal chromosomal abnormalities
* Severe IUGR
* Significant intracranial hemorrhage with a large intracranial hemorrhage (Grade III or intraparenchymal echodensity (Grade IV))
Minimum Eligible Age

1 Day

Maximum Eligible Age

3 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael D Weiss, MD

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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University of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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IRB201501109

Identifier Type: -

Identifier Source: org_study_id

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