QST-Pupillometry in Sickle Cell Disease Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-08-31

Study Completion Date

2018-11-30

Brief Summary

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There has been little progress for effective treatment of pain in sickle cell disease (SCD) patients. Many organizations have recognized that understanding the causes and reducing the burden of pain in SCD is critical in order to improve the quality of life in SCD patients. As patients with SCD face the challenge of living with both acute and chronic pain which is often improperly treated, our translational and interdisciplinary project aims to identify objective measures of pain sensitivity and its biochemical and genetic correlates. We hypothesize that SCD patients will have decreased tolerance to thermal and electrical stimuli.

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Detailed Description

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Conditions

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SCD With Severe Phenotype (HbSS, HbSβ0 Thalassemia, HbSOARab)

Study Design

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Observational Model Type

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Inclusion Criteria

* SCD with severe phenotype (HbSS, HbSbeta0 thalassemia, HbSOArab)
* Relatives of SCD patients who do not have sickle cell trait or SCD; healthy controls

Exclusion Criteria

* Completed overt clinical stroke or transient ischemic attack;
* Known severe vasculopathy or Moyamoya disease on brain MRA (Magnetic Resonance Angiography).
* history of having consumed alcohol within the last 12 hours prior to testing.

Minimum Eligible Age

13 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes