Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

NCT ID: NCT02239120

Last Updated: 2019-09-06

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

5390 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-27

Study Completion Date

2018-08-14

Brief Summary

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This trial will enroll approximately 6,000 patients with recent embolic stroke of unknown source (ESUS). Patients will be randomized to dabigatran or acetylsalicyclic acid (ASA) (1:1 ratio) and have visits every three months. The study doctor may prescribe blinded concomitant ASA for pts with coronary artery disease but this is not mandatory. All Adverse Events (AEs), Serious Adverse Events (SAEs), outcome events will be recorded. The trial will conclude when the required number of stroke events are positively adjudicated which is estimated to take 3 years (including 2.5 years of enrollment).

Detailed Description

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Conditions

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Stroke Secondary Prevention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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dabigatran etexilate 110 or 150 mg

Patients will be assigned Dabigatran 150 mg b.i.d. (unless they are 75 years or older, or have a Creatinine Clearance (CrCl) of greater than or equal to 30 to less than 50ml/min (or experience GI bleed during trial), in which case they will receive Dabigatran 110 mg b.i.d.). All patients in this arm will also receive ASA placebo (q.d.)

Group Type EXPERIMENTAL

optional ASA as comedication

Intervention Type DRUG

optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

placebo to ASA

Intervention Type DRUG

placebo to comparator drug

dabigatran etexilate

Intervention Type DRUG

active drug

ASA 100 mg

All patients will receive blinded ASA 100 mg q.d. and dabigatran placebo 150 mg b.i.d. (unless they are 75 years or older, or have a CrCl of greater than or equal to 30 to less than 50ml/min (or experience GI bleed during trial), in which case they will receive placebo Dabigatran 110 mg b.i.d

Group Type ACTIVE_COMPARATOR

placebo to optional ASA as comedication

Intervention Type DRUG

optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

placebo to dabigatran etexilate

Intervention Type DRUG

placebo

ASA 100 mg

Intervention Type DRUG

active comparator drug

Interventions

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optional ASA as comedication

optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

Intervention Type DRUG

placebo to ASA

placebo to comparator drug

Intervention Type DRUG

placebo to optional ASA as comedication

optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

Intervention Type DRUG

placebo to dabigatran etexilate

placebo

Intervention Type DRUG

ASA 100 mg

active comparator drug

Intervention Type DRUG

dabigatran etexilate

active drug

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Ischemic stroke with a brain lesion visualized by neuroimaging (either brain Computed Tomography (CT) or Magnetic Resonance Image (MRI)). The visualized stroke is a non-lacunar infarct , e.g. involving the cortex or \>1.5 cm (\>2.0 cm if measured on MRI diffusion-weighted images) in largest diameter if exclusively subcortical.Visualization by CT usually requires delayed imaging \>24-48 hours after stroke onset.
* The index stroke must have occurred either up to 3 months before randomization (Modified Rankin Scale(mRS) \<=3 at randomization) or up to 6 months before randomization (mRS \<=3 at randomization) in selected patients that are \>= 60 years plus at least one additional risk factor for recurrent stroke.
* Arterial imaging or cervical plus Transcranial Doppler (TCD) ultrasonography does not show extra-cranial or intracranial atherosclerosis with \>= 50% luminal stenosis in artery supplying the area of acute ischemia.
* As evidenced by cardiac monitoring for \>= 20 hours with automated rhythm detection, there is absence of AF \> 6 minutes in duration (within a 20 hour period, either as single episode or cumulative time of multiple episodes).

Exclusion Criteria

* Modified Rankin Scale of \>=4 at time of randomization or inability to swallow medications.
* Major risk cardioembolic source of embolism such as: a) intracardiac thrombus as evidenced by transthoracic or transesophageal echocardiography, b) paroxysmal, persistent or permanent Atrial fibrillation (AF), c) atrial flutter, d) prosthetic cardiac valve (mitral or aortic, bioprosthetic or mechanical), e) atrial myxoma, f) other cardiac tumors, g) moderate or severe mitral stenosis, h) recent (\< 4weeks) myocardial infarction, i) valvular vegetations, or j) infective endocarditis.
* Any indication that requires treatment with an anticoagulant as per Investigator's judgment.
* History of atrial fibrillation (unless it was due to reversible causes such as hyperthyroidism or binge drinking, and has been permanently resolved).
* Other specific stroke etiology (i.e. cerebral arteritis or arterial dissection, migraine with aura/vasospasm, drug abuse).
* Renal impairment with estimated creatinine clearance (as calculated by Cockcroft-Gault equation) \<30mL/min at screening, or where Investigator expects creatinine clearance is likely to drop below 30mL/min during the course of the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

150 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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Bronislava Shafran, MD PC

Phoenix, Arizona, United States

Site Status

Westside Medical Associates of Los Angeles

Beverly Hills, California, United States

Site Status

TriWest Research Associates, LLC

El Cajon, California, United States

Site Status

University of California

Fresno, California, United States

Site Status

Glendale Adventist Medical Center

Glendale, California, United States

Site Status

Collaborative Neuroscience Network, LLC (CNS)

Long Beach, California, United States

Site Status

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

Site Status

University of California Los Angeles

Los Angeles, California, United States

Site Status

Huntington Hospital

Pasadena, California, United States

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University of California

San Diego, California, United States

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University of California

San Francisco, California, United States

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University of Colorado Denver

Aurora, Colorado, United States

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Colorado Neurological Institute

Englewood, Colorado, United States

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University of Colorado Denver

Fort Collins, Colorado, United States

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St. Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, United States

Site Status

Hartford Hospital

Hartford, Connecticut, United States

Site Status

JEM Research Institute

Atlantis, Florida, United States

Site Status

Boca Raton Regional Hospital

Boca Raton, Florida, United States

Site Status

Tenet Florida Physician Services

Boynton Beach, Florida, United States

Site Status

Nova Clinical Research, LLC

Bradenton, Florida, United States

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Broward Health North

Deerfield Beach, Florida, United States

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Center for Advanced Research Excellence

Hialeah, Florida, United States

Site Status

Bruce W. Carter, Miami VA Healthcare System

Miami, Florida, United States

Site Status

University of Miami

Miami, Florida, United States

Site Status

Bay Neurological Institute

Panama City, Florida, United States

Site Status

Carol L Pappas, MD PhD PA

St. Petersburg, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Vero Beach Neurology and Research Institute

Vero Beach, Florida, United States

Site Status

Palm Beach Neuroscience Institute

West Palm Beach, Florida, United States

Site Status

Augusta University

Augusta, Georgia, United States

Site Status

WellStar Medical Group - Neurosurgery

Marietta, Georgia, United States

Site Status

The Queen's Medical Center

Honolulu, Hawaii, United States

Site Status

Saint Alphonsus Medical Center-Neurology

Boise, Idaho, United States

Site Status

Northwest Heart Clinical Research, LLC

Arlington Heights, Illinois, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

University of Chicago

Chicago, Illinois, United States

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Medicoricium, LLC

Fairview Heights, Illinois, United States

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OSF Saint Francis Medical Center

Peoria, Illinois, United States

Site Status

Quincy Physicians and Surgeons Clinic, S.C.

Quincy, Illinois, United States

Site Status

Southern Illinois University School of Medicine

Springfield, Illinois, United States

Site Status

Community Clinical Research Center

Anderson, Indiana, United States

Site Status

Ruan Neurology Clinic and Research Center

Des Moines, Iowa, United States

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Associates in Neurology, PSC

Lexington, Kentucky, United States

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University of Louisville

Louisville, Kentucky, United States

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Alexandria Cardiology Clinic

Alexandria, Louisiana, United States

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Culicchia Neurological Clinic

Marrero, Louisiana, United States

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Tulane University Hospital and Clinic

New Orleans, Louisiana, United States

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Ochsner Medical Center

New Orleans, Louisiana, United States

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Anne Arundel Medical Center

Annapolis, Maryland, United States

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Johns Hopkins Hospital

Baltimore, Maryland, United States

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Massachusetts General Hospital

Boston, Massachusetts, United States

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Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

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Newton-Wellesley Hospital

Newton, Massachusetts, United States

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Henry Ford Health System

Detroit, Michigan, United States

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McLaren Flint

Flint, Michigan, United States

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Mercy Health Saint Mary's

Grand Rapids, Michigan, United States

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Spectrum Health Medical Center

Grand Rapids, Michigan, United States

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Sparrow Clinical Research Institute

Lansing, Michigan, United States

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St. Joseph Mercy Oakland

Pontiac, Michigan, United States

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The Duluth Clinic dba Essentia Health Duluth Clinic

Duluth, Minnesota, United States

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Abbott Northwestern Hospital, Radiology Department

Minneapolis, Minnesota, United States

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HealthPartners Neuroscience Center

Saint Paul, Minnesota, United States

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Jackson Heart Clinic, P.A.

Jackson, Mississippi, United States

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Boone Hospital Center

Columbia, Missouri, United States

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University of Missouri Health System

Columbia, Missouri, United States

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SSM Health St. Clare Hospital

Fenton, Missouri, United States

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Saint Luke's Hospital of Kansas City

Kansas City, Missouri, United States

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Saint Louis University

St Louis, Missouri, United States

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St. Louis Heart and Vascular, P.C.

St Louis, Missouri, United States

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The Nebraska Medical Center

Omaha, Nebraska, United States

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Renown Institute for Neurosciences

Reno, Nevada, United States

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NYC Health + Hospitals/Coney Island

Brooklyn, New York, United States

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New York Presbyterian Hudson Valley Hospital

Cortlandt Manor, New York, United States

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UHS Wilson Medical Center,Office of Clin Trials

Johnson City, New York, United States

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North Shore University Hospital

Manhasset, New York, United States

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Winthrop University Hospital

Mineola, New York, United States

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Mount Sinai Beth Israel

New York, New York, United States

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Novant Health Neurology Specialists

Charlotte, North Carolina, United States

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Duke Clinic 1L

Durham, North Carolina, United States

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Cone Health System

Greensboro, North Carolina, United States

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Novant Health Neurology Hickory

Hickory, North Carolina, United States

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Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

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Altru Health System

Grand Forks, North Dakota, United States

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The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

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Holzer Clinic LLC

Gallipolis, Ohio, United States

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Advanced Neurology Associates

Youngstown, Ohio, United States

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Oregon Health and Sciences University

Portland, Oregon, United States

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Veterans Affairs Portland Health Care System

Portland, Oregon, United States

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Sacred Heart Medical Center at RiverBend

Springfield, Oregon, United States

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Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

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Thomas Jefferson University

Philadelphia, Pennsylvania, United States

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Temple University Hospital

Philadelphia, Pennsylvania, United States

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Abington Neurological Associates

Willow Grove, Pennsylvania, United States

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Rhode Island Hospital

Providence, Rhode Island, United States

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Greenville Memorial Hospital

Greenville, South Carolina, United States

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Methodist University Hospital

Memphis, Tennessee, United States

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Centennial Heart Cardiovascular Consultants, LLC

Nashville, Tennessee, United States

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Saint Thomas Health

Nashville, Tennessee, United States

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Seton Medical Center Austin

Austin, Texas, United States

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Houston Methodist Hospital

Houston, Texas, United States

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Bhupesh Dihenia, M.D.,P.A.

Lubbock, Texas, United States

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University of Vermont

Burlington, Vermont, United States

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Virginia Commonwealth University

Richmond, Virginia, United States

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Carilion Riverside

Roanoke, Virginia, United States

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Virginia Mason Medical Center

Seattle, Washington, United States

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Swedish Neuroscience Institute

Seattle, Washington, United States

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Marshall University

Huntington, West Virginia, United States

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Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

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University of Wisconsin

Madison, Wisconsin, United States

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STAT Research

CABA, , Argentina

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Fundación Favaloro

CABA, , Argentina

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Hospital Italiano de Buenos Aires

CABA, , Argentina

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Clinica Coronel Suarez SA

Coronel Suárez, , Argentina

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Instituto Médico DAMIC S.R.L.

Córdoba, , Argentina

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Hospital Privado de Comunidad

Mar del Plata, , Argentina

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Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

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St Vincent's Hospital Sydney

Darlinghurst, New South Wales, Australia

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Kanwal Medical Complex

Kanwal, New South Wales, Australia

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John Hunter Hospital

New Lambton, New South Wales, Australia

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Royal North Shore Hospital

St Leonards, New South Wales, Australia

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Sunshine Coast University Hospital

Birtinya, Queensland, Australia

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Royal Brisbane and Women's Hospital

Herston, Queensland, Australia

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Royal Adelaide Hospital

Adelaide, South Australia, Australia

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Calvary North Adelaide Hospital

Adelaide, South Australia, Australia

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Box Hill Hospital

Box Hill, Victoria, Australia

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Austin Health

Heidelberg, Victoria, Australia

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Royal Melbourne Hospital

Parkville, Victoria, Australia

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Alfred Health

Victoria, Victoria, Australia

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LKH-Univ. Hospital Graz

Graz, , Austria

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Medical University of Innsbruck

Innsbruck, , Austria

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Kepler Univ. Klinikum Linz

Linz, , Austria

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Kepler Univ. Klinikum Linz

Linz, , Austria

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KH d. Barmherzigen Brüder Linz, Neurologie

Linz, , Austria

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Universitätsklinikum Tulln, Abteilung für Neurologie

Tulln, , Austria

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Hosp.Hietzing with Neuro.Centr Rosenhuegel,II Neuro.dep,Wien

Vienna, , Austria

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Wilhelminenspital

Vienna, , Austria

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Aalst - HOSP Onze-Lieve-Vrouw

Aalst, , Belgium

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Arlon - HOSP Sud Luxembourg - Vivalia

Arlon, , Belgium

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AZ Sint-Jan Brugge

Bruges, , Belgium

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Brussels-UNIV Brugmann -Horta

Brussels, , Belgium

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Brussels - HOSP Europe (Ste-Elisabeth)

Brussels, , Belgium

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Brussels - UNIV Saint-Luc

Brussels, , Belgium

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UNIV UZ Gent

Ghent, , Belgium

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Kortrijk - HOSP AZ Groeninge Kennedylaan

Kortrijk, , Belgium

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UZ Leuven

Leuven, , Belgium

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Liège - HOSP St-Joseph

Liège, , Belgium

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Roeselare - HOSP AZ Delta

Roeselare, , Belgium

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Rumst - HOSP AZ Heilige Familie

Rumst, , Belgium

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Sint-Truiden - HOSP St-Trudo (St-Jozef)

Sint-Truiden, , Belgium

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Wilrijk - HOSP GZA (St-Augustinus)

Wilrijk, , Belgium

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Yvoir - UNIV UCL de Mont-Godinne

Yvoir, , Belgium

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Hospital Clinicas de Botucatu

Botucatu, , Brazil

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Instituto de Medicina Flumignano

Curitiba, , Brazil

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Clinica Neurologica e Neurocirurgica de Joinvile

Joinvile, , Brazil

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Hospital de Clínicas de Porto Alegre

Porto Alegre, , Brazil

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H.C.da Fac. de Medicina de Ribeirao Preto

Ribeirão Preto, , Brazil

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Hospital Quinta D¿Or

Rio de Janeiro, , Brazil

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Foothills Medical Centre

Calgary, Alberta, Canada

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University of Alberta Hospital (University of Alberta)

Edmonton, Alberta, Canada

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Grey Nuns Hospital

Edmonton, Alberta, Canada

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Prairie Mountain Health

Brandon, Manitoba, Canada

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Hopital Notre-Dame du CHUM

Montreal, Migration Data, Canada

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Jewish General Hospital

Montreal, Migration Data, Canada

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Saint John Regional Hospital

Saint John, New Brunswick, Canada

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Eastern Health (MUN)

St. John's, Newfoundland and Labrador, Canada

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Victoria Hospital (LHSC)

London, Ontario, Canada

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St. Michael's Hospital

Toronto, Ontario, Canada

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Toronto Western Hospital

Toronto, Ontario, Canada

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CSSS de Chicoutimi

Chicoutimi, Quebec, Canada

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Hopital Charles - LeMoyne

Greenfield Park, Quebec, Canada

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Montreal General Hospital - McGill University Health Centre

Montreal, Quebec, Canada

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St Jerome Medical Research Inc.

Saint-Jérôme, Quebec, Canada

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CHUS Fleurimont

Sherbrooke, Quebec, Canada

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CHU de Quebec-Universite Laval Research Centre

Québec, , Canada

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Clínica Alemana de Santiago S.A.

Santiago, , Chile

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Clínica Dávila

Santiago, , Chile

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Clinica Alemana de Temuco

Temuco, , Chile

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Beijing Tiantan Hospital affiliated to Cap Med University

Beijing, , China

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Peking University Third Hospital

Beijing, , China

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First Hospital of Jilin University

Changchun, , China

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First Affiliated Hospital of Guangzhou Medical University

Guangzhou, , China

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First Affiliated Hospital of Guangzhou University of TCM

Guangzhou, , China

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The First Affiliated Hospital of Jinan University

Guangzhou, , China

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The Affiliated Hospital of Guizhou Medical University

Guiyang, , China

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2nd Affiliated Hosp Zhejiang University College of Medical

Hangzhou, , China

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Zhejiang Hospital

Hangzhou, , China

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The Affiliated Hospital of Hangzhou Normal University

Hangzhou, , China

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Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital

Hangzhou, , China

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Jinlin Central Hospital

Jilin, , China

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The Second Affiliated Hospital to Nanchang University

Nanchang, , China

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Nanjing Drum Tower Hospital

Nanjing, , China

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Zhongda Hospital Southeast University

Nanjing, , China

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QingDao Municipal Hospital

Qingdao, , China

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The affiliated hospital of medicalcollege qingdao university

Qingdao, , China

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Huashan Hospital, Fudan University

Shanghai, , China

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Tongji Hospital, Tongji University

Shanghai, , China

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General Hospital of Shenyang Military Region

Shenyang, , China

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First Affiliated Hospital of Xiamen University

Xiamen, , China

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Affiliated Hospital, Xuzhou Medical college

Xuzhou, , China

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Servicios Médicos Muñoz Solano

Bogotá, , Colombia

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Sociedad de Cirugia de Bogota Hospital de San José

Bogotá, , Colombia

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Fundación Valle del Lili

Cali, , Colombia

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Fundación Cardiovascular de Colombia

Floridablanca, , Colombia

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General Hospital Varazdin

Varaždin, , Croatia

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Clin.Hosp.Centre Zagreb,Cerebrovascul.disease w/ intens.care

Zagreb, , Croatia

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University hospital center Zagreb

Zagreb, , Croatia

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Univ. Hosp. Sisters of Mercy, Neurology Clinic, Zagreb

Zagreb, , Croatia

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Cerebrovascular site, private prac., Brno

Brno, , Czechia

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Hospital Jihlava

Jihlava, , Czechia

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University Hospital Olomouc

Olomouc, , Czechia

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Cerebrovascular site, Ostrava

Ostrava, , Czechia

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Cerebrovascular site, Ostrava

Ostrava, , Czechia

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University Hospital Motol

Prague, , Czechia

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Hospital Homolka, Prague

Prague, , Czechia

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East Estonia Central Hospital, Neurology Dept, Ahtme

Ahtme, , Estonia

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West Tallinn Central Hospital, Neurology Dept.

Tallinn, , Estonia

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North Estonia Medical Centre Foundation, Tallin

Tallinn, , Estonia

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Tartu University Hospital

Tartu, , Estonia

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HOP Pays d'Aix

Aix-en-Provence, , France

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HOP de Bayonne

Bayonne, , France

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HOP Jean Minjoz

Besançon, , France

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HOP Pellegrin

Bordeaux, , France

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HOP de la Cavale Blanche

Brest, , France

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HOP Pierre Wertheimer

Bron, , France

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HOP Côte de Nacre

Caen, , France

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HOP Grenoble, Neuro, Grenoble

Grenoble, , France

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HOP Roger Salengro

Lille, , France

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HOP Mercy

Metz, , France

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HOP Paris Saint-Joseph

Paris, , France

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GHU Paris Psychiatrie et Neurosciences

Paris, , France

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HOP Purpan

Toulouse, , France

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Klinikum Altenburger Land GmbH

Altenburg, , Germany

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Neurologische Klinik GmbH, Bad Neustadt

Bad Neustadt an der Saale, , Germany

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Vivantes Netzwerk für Gesundheit GmbH

Berlin, , Germany

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Evangelisches Klinikum Bethel gGmbH

Bielefeld, , Germany

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Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH

Bochum, , Germany

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St. Josef- und St. Elisabeth-Hospital gGmbH

Bochum, , Germany

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Gesundheit Nord gGmbH | Klinikverbund Bremen

Bremen, , Germany

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Klinikum Bremerhaven

Bremen, , Germany

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Krankenhäuser Buchholz und Winsen gGmbH

Buchholz, , Germany

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Allgemeines Krankenhaus, Celle

Celle, , Germany

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Klinikum Chemnitz gGmbH

Chemnitz, , Germany

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Klinikum Coburg gGmbH

Coburg, , Germany

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Universitätsklinikum Köln (AöR)

Cologne, , Germany

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Klinikzentrum Mitte, Dortmund

Dortmund, , Germany

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Städtisches Klinikum Dresden

Dresden, , Germany

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Universitätsklinikum Carl Gustav Carus Dresden

Dresden, , Germany

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Universitätsklinikum Düsseldorf

Düsseldorf, , Germany

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Marien-Hospital, Düsseldorf

Düsseldorf, , Germany

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Universitätsklinikum Erlangen

Erlangen, , Germany

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Alfried Krupp Krankenhaus Essen

Essen, , Germany

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Universitätsklinikum Essen AöR

Essen, , Germany

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Klinikum Frankfurt Höchst GmbH

Frankfurt, , Germany

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Universitätsklinikum Frankfurt

Frankfurt am Main, , Germany

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Klinikum Friedrichshafen

Friedrichshafen, , Germany

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Klinikum Fulda gAG

Fulda, , Germany

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Evangelische Klinik Gelsenkirchen

Gelsenkirchen, , Germany

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SRH Wald-Klinikum Gera GmbH

Gera, , Germany

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Universitätsklinikum Gießen und Marburg GmbH

Giessen, , Germany

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Universitätsmedizin Greifswald

Greifswald, , Germany

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Bezirkskrankenhaus, Günzburg

Günzburg, , Germany

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Asklepios Klinik St. Georg

Hamburg, , Germany

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Universitätsklinikum Hamburg-Eppendorf

Hamburg, , Germany

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Asklepios Klinik Harburg

Hamburg, , Germany

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Asklepios Klinik Wandsbek

Hamburg, , Germany

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Asklepios Klinik Barmbek

Hamburg, , Germany

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Asklepios Klinik Altona

Hamburg, , Germany

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Klinikum Hanau GmbH

Hanau, , Germany

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Medizinische Hochschule Hannover

Hanover, , Germany

Site Status

Universitätsklinikum Heidelberg

Heidelberg, , Germany

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SLK-Kliniken Heilbronn GmbH

Heilbronn, , Germany

Site Status

Klinikum Idar-Oberstein

Idar-Oberstein, , Germany

Site Status

Universitätsklinikum Jena

Jena, , Germany

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Universitätsklinikum Schleswig-Holstein, Campus Kiel

Kiel, , Germany

Site Status

Universitätsklinikum Leipzig

Leipzig, , Germany

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Klinikum der Stadt Ludwigshafen am Rhein gGmbH

Ludwigshafen, , Germany

Site Status

Universitätsklinikum Magdeburg AöR

Magdeburg, , Germany

Site Status

Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, , Germany

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Universitätsklinikum Gießen und Marburg GmbH

Marburg, , Germany

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Elblandklinikum Meißen

Meißen, , Germany

Site Status

Johannes Wesling Klinikum

Minden, , Germany

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Kliniken Maria Hilf GmbH

Mönchengladbach, , Germany

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Ökumenisches Hainich Klinikum gGmbH

Mühlhausen, , Germany

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Klinikum der Universität München - Campus Großhadern

München, , Germany

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Klinikum rechts der Isar der Technischen Universität München

München, , Germany

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Universitätsklinikum Münster

Münster, , Germany

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Klinikum Nürnberg

Nuremberg, , Germany

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Sana Klinikum Offenbach GmbH

Offenbach, , Germany

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Klinikum Osnabrück GmbH

Osnabrück, , Germany

Site Status

Universitätsklinikum Regensburg

Regensburg, , Germany

Site Status

Nordwest-Krankenhaus Sanderbusch gGmbH

Sande, , Germany

Site Status

Kreisklinikum Siegen GmbH

Siegen, , Germany

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Bürgerhospital, Stuttgart

Stuttgart, , Germany

Site Status

Nervenklinik Teupitz, Teupitz

Teupitz, , Germany

Site Status

Krankenhaus der Barmherzigen Brüder Trier

Trier, , Germany

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Universitätsklinikum Tübingen

Tübingen, , Germany

Site Status

RKU - Universitäts- und Rehabilitationskliniken Ulm gGmbH

Ulm, , Germany

Site Status

Sophien- und Hufeland-Klinikum gGmbH

Weimar, , Germany

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Helios Dr. Horst Schmidt Kliniken Wiesbaden

Wiesbaden, , Germany

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Universitätsklinikum Würzburg

Würzburg, , Germany

Site Status

Univ.Hosp. of Alexandroupolis

Alexandroupoli, , Greece

Site Status

Gen.Hosp.of Ath.Evangelismos

Athens, , Greece

Site Status

Attikon University Hospital

Athens, , Greece

Site Status

Gen.Univ. Hosp. of Herakleion

Heraklion, , Greece

Site Status

General University Hospital of Larissa

Larissa, , Greece

Site Status

Univ. Gen. Hosp. of Patras

Pátrai, , Greece

Site Status

Univ.Gen.Hosp. of Thessaloniki

Thessaloniki, , Greece

Site Status

Prince of Wales Hospital

Hong Kong, , Hong Kong

Site Status

Pamela Youde Nethersole Eastern Hospital

Hong Kong, , Hong Kong

Site Status

Queen Mary Hospital

Hong Kong, , Hong Kong

Site Status

Semmelweis University

Budapest, , Hungary

Site Status

National Instit.of Neurosciences,Neurology Dept,Budapest

Budapest, , Hungary

Site Status

Univ. Debrecen Medical Health Science Center, Neurology Dept

Debrecen, , Hungary

Site Status

Pest Megyei Flor Ferenc Hospital

Kistarcsa, , Hungary

Site Status

CRU Hungary Ltd, Private Practice, Miskolc

Miskolc, , Hungary

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Univ. of Pecs Clinic for Neurology

Pécs, , Hungary

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St. Johns medical College and Hospital

Bangalore, , India

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Post Graduate Institute of Medical Education and Research

Chandigarh, , India

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Lalitha Super Specialities Hospital

Guntur, , India

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Nizam's Institute of Medical Sciences

Hyderabad, , India

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Shree Krishna Hospital and Research Centre

Karamsad, , India

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Caritas Hospital

Kottayam, , India

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Mangala Hospital and Mangala Kidney Foundation

Mangalore, , India

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LTMMC & GH Medical College,

Mumbai, , India

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Magnum Heart Institute

Nashik, , India

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All India Institute of Medical Sciences

New Delhi, , India

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Sahyadri Speciality Hospital

Pune, , India

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Hillel Yaffe Medical Center, Hadera

Hadera, , Israel

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Wolfson Medical Center

Holon, , Israel

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The Chaim Sheba Medical Center Tel Hashomer

Tel Hashomer, Ramat Gan, , Israel

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Sourasky Medical Center

Telaviv, , Israel

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Osp. SS Filippo Nicola

Avezzano, , Italy

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Policlinico S. Orsola Malpighi

Bologna, , Italy

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A.O. Spedali Civili di Brescia

Brescia, , Italy

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Azienda Ospedaliero Universitaria di Ferrara

Cona (FE), , Italy

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Policlinico San Martino

Genova, , Italy

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A.O.U.Policlinico G.Martino

Messina, , Italy

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Fondazione Centro San Raffaele del Monte Tabor

Milan, , Italy

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Istituto Auxologico Italiano

Milan, , Italy

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Nuovo Ospedale Civile S. Agostino-Estense

Modena, , Italy

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Azienda Ospedaliera Universitaria di Padova

Padua, , Italy

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Ospedale S.Maria della Misericordia, AO di Perugia

Perugia, , Italy

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Osp. Guglielmo da Saliceto AUSL di Piacenza

Piacenza, , Italy

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Ospedale Santa Corona Azienda Sanitaria Locale n.2 Savonese

Pietra Ligure, , Italy

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Università degli Studi Campus Bio-Medico

Roma, , Italy

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A.O. San Camillo Forlanini

Roma, , Italy

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Umberto I Pol. di Roma-Università di Roma La Sapienza

Roma, , Italy

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Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza

Roma, , Italy

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A.O.U. Senese Policlinico Santa Maria alle Scotte

Siena, , Italy

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Ospedale Molinette, AO Città della Salute e della

Torino, , Italy

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Ospedale Maria Vittoria

Torino, , Italy

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Ospedale S. Maria di Ca' Foncello Azienda ULSS9 TREVISO

Treviso, , Italy

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A. O. Ospedale Circolo Fond. Macchi

Varese, , Italy

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Ospedale Policlinico G.B. Rossi (Borgo Roma) di Verona

Verona, , Italy

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Chubu Rosai Hospital

Aichi, Nagoya, , Japan

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National Hospital Organization Toyohashi Medical Center

Aichi, Toyohashi, , Japan

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Toyota Memorial Hospital

Aichi, Toyota, , Japan

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Reserch Institute for Brain and Blood Vessels Akita

Akita, Akita, , Japan

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Juntendo University Urayasu Hospital

Chiba, Urayasu, , Japan

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Go Neurosurgical Clinic

Fukuoka, Chikushi-gun, , Japan

Site Status

Fukuoka University Chikushi Hospital

Fukuoka, Chikushino, , Japan

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National Hospital Organization Kyushu Medical Center

Fukuoka, Fukuoka, , Japan

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Fukuoka Wajiro Hospital

Fukuoka, Fukuoka, , Japan

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Fukuoka University Hospital

Fukuoka, Fukuoka, , Japan

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Fukuoka Tokushukai Medical Center

Fukuoka, Kasuga, , Japan

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Steel Memorial Yawata Hospital

Fukuoka, Kitakyushu, , Japan

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Japan Community Health Care Organization Kyushu Hospital

Fukuoka, Kitakyushu, , Japan

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St. Mary's Hospital

Fukuoka, Kurume, , Japan

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Shin Koga Hospital

Fukuoka, Kurume, , Japan

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Fukuoka Shin Mizumaki Hospital

Fukuoka, Onga, , Japan

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Social Insurance Tagawa Hospital

Fukuoka, Tagawa, , Japan

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Shin Yukuhashi Hospital

Fukuoka, Yukuhashi, , Japan

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Fujita General Hospital

Fukushima, Date-Gun, , Japan

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Shinseikai Masu Memorial Hospital

Fukushima, Nihonmatsu, , Japan

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Asahi University Hospital

Gifu, Gifu, , Japan

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Japanese Red Cross Takayama Hospital

Gifu, Takayama, , Japan

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Mihara Memorial Hospital

Gunma, Isesaki, , Japan

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Maebashi Red Cross Hospital

Gunma, Maebashi, , Japan

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Medical corporation Suiseikai Suiseikai Kajikawa Hospital

Hiroshima, Hiroshima, , Japan

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Araki Neurosurgical Hospital

Hiroshima, Hiroshima, , Japan

Site Status

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, , Japan

Site Status

Sapporo Shiroishi Memorial Hospital

Hokkaido, Sapporo, , Japan

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Nakamura Memorial Hospital

Hokkaido, Sapporo, , Japan

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Kobe City Medical Center General Hospital

Hyogo, Kobe, , Japan

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JA Toride Medical Center

Ibaraki, Toride, , Japan

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Tsukuba Medical Center Hospital

Ibaraki, Tsukuba, , Japan

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Iwate Medical University Hospital

Iwate, Morioka, , Japan

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Kagoshima City Hospital

Kagoshima, Kagoshima, , Japan

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National Hospital Organization Kagoshima Medical Center

Kagoshima, Kagoshima, , Japan

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Shonan Kamakura General Hospital

Kanagawa, Kamakura, , Japan

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Saiseikai Kumamoto Hospital

Kumamoto, Kumamoto, , Japan

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Japanese Red Cross Kumamoto Hospital

Kumamoto, Kumamoto, , Japan

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Kumamoto City Hospital

Kumamoto, Kumamoto, , Japan

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Uji-Tokushukai Medical Center

Kyoto, Uji, , Japan

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National Hospital Organization Sendai Medical Center

Miyagi, Sendai, , Japan

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South Miyagi Medical Center

Miyagi, Shibata-gun, , Japan

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Ina Central Hospital

Nagano, Ina, , Japan

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Nagano Municipal Hospital

Nagano, Naganoi, , Japan

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Nagasaki University Hospital

Nagasaki, Nagasaki, , Japan

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Nozaki Tokushukai Hospital

Osaka, Daito, , Japan

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Higashiosaka City Medical Center

Osaka, Higashiosaka, , Japan

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Wakakusa Daiichi Hospital

Osaka, Higashiosaka, , Japan

Site Status

Rinku General Medical Center

Osaka, Izumisano, , Japan

Site Status

Kishiwada Tokushukai Hospital

Osaka, Kishiwada, , Japan

Site Status

Yagi Neurosurgical Hospital

Osaka, Osaka, , Japan

Site Status

Tominaga Hospital

Osaka, Osaka, , Japan

Site Status

Osaka University Hospital

Osaka, Suita, , Japan

Site Status

TMG Asaka Medical Center

Saitama, Asaka, , Japan

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Saitama Medical University International Medical Center

Saitama, Hidaka, , Japan

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Sainokuni Higashiomiya Medical Center

Saitama, Saitama, , Japan

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Saitama Municipal Hospital

Saitama, Saitama, , Japan

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Nippon Medical School Hospital

Tokyo, Bunkyo-ku, , Japan

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Tokyo Metropolitan Geriatric Hospital

Tokyo, Itabashi-ku, , Japan

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Kyorin University Hospital

Tokyo, Mitaka, , Japan

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Tokyo Women's Medical University Hospital

Tokyo, Shinjuku-ku, , Japan

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Saiseikai Wakayama Hospital

Wakayama, Wakayama, , Japan

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Yamagata City Hospital SAISEIKAN

Yamagata, Yamagata, , Japan

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Sarawak General Hospital

Kuching, , Malaysia

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Hospital Seberang Jaya

Pulau Pinang, , Malaysia

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Hospital Sultanah Nur Zahirah

Terengganu, , Malaysia

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Hospital General de Culiacán "Dr. Bernardo J. Gastellum"

Culiacán, , Mexico

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Hospital Angeles del Pedregal

México, D.F., , Mexico

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Hospital General "Dr. Miguel Silva"

Morelia, , Mexico

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Hospital Universitario Dr Jose Eleuterio Gonzalez

Nuevo León, , Mexico

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H. Central Dr Ignacio M. P.

San Luis Potosí City, , Mexico

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Auckland City Hospital

Grafton / Auckland, , New Zealand

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North Shore Hospital, Takapuna

Takpuna Auckland, , New Zealand

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Wellington Hospital

Wellington, , New Zealand

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Instituto Nacional de Ciencias Neurológicas

Barrios Altos, , Peru

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Hospital Nacional Guillermo Almenara Irigoyen

La Victoria, , Peru

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PI HOUSE Sp. z o.o., Gdansk

Gdansk, , Poland

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Spec.Hosp.of Dr. Wladyslaw Bieganski in Grudziadz

Grudziądz, , Poland

Site Status

Univ.Clin.Centr Gibinski of Silesian Med,Neurol.dep,Katowice

Katowice, , Poland

Site Status

University Hospital in Krakow

Krakow, , Poland

Site Status

Center of Clinical Neurology, private prac, Krakow

Krakow, , Poland

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Clin.Research Center,Leszek Szczepanski,Private Prac.,Lublin

Lublin, , Poland

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Medicome Sp. z o.o.

Oświęcim, , Poland

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Specialist Holy Spirit Hospital, Neurology Dept,Sandomierz

Sandomierz, , Poland

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Public Central Clinical Hosp,Neurology Clinic,Warsaw

Warsaw, , Poland

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Military Institute of Medicine Neurology Clinic, Warsaw

Warsaw, , Poland

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Hospital Garcia de Orta, EPE

Almada, , Portugal

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Hospital Fernando Fonseca, EPE

Amadora, , Portugal

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Hospital de Braga - Centro Clínico Académico (2CA)

Braga, , Portugal

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CHUC - Centro Hospitalar e Universitário de Coimbra, EPE

Coimbra, , Portugal

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CHLC, EPE - Hospital de São José

Lisbon, , Portugal

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CHLO, EPE - Hospital Egas Moniz

Lisbon, , Portugal

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CHULN, EPE - Hospital de Santa Maria

Lisbon, , Portugal

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Hospital Beatriz Ângelo

Loures, , Portugal

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USLM, EPE - Hospital Pedro Hispano

Matosinhos Municipality, , Portugal

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H. Santo António - Centro Hospitalar do Porto

Porto, , Portugal

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Centro Hospitalar São João,EPE

Porto, , Portugal

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Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião

Santa Maria da Feira, , Portugal

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Interreg. Clinical & Diagnostic Center, Neurol. Dept., Kazan

Kazan', , Russia

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Reg.Clin.Hosp#1 na S.V.Ochapovskiy,Neurology#1 Dep,Krasnodar

Krasnodar, , Russia

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City Clin.Emergency Hosp of Kursk, Neurology Department No.2

Kursk, , Russia

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Clin.Hosp#2,na.Semashko,Russ.Railways,Restorative Med&Rehab.

Moscow, , Russia

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CityClin.Hosp na I.V.Davydovsky of Dept of Healthcare Moscow

Moscow, , Russia

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Research&Clini Cent Neuropsychiatry Dep. Healthcare,Moscow

Moscow, , Russia

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City Clin.Hosp#1na N.I.Pirogov,Dept of Healthcare of Moscow

Moscow, , Russia

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Ltd liabilityCom.CityNeurologic Cntr Sibneiromed,Novosibirsk

Novosibirsk, , Russia

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Research Inst. of Emerg. Med., Vascul. Center,St. Petersburg

Saint Petersburg, , Russia

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Military Medical Academy n.a. C. M. Kirov, St. Petersburg

Saint Petersburg, , Russia

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Saratov State Med.Univ na V.I.Razumovsky,FacultyTherapy Clin

Saratov, , Russia

Site Status

Reg.State Instit.of Healthc.Smolensk Reg.Clin.Hosp,Neurology

Smolensk, , Russia

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Sverdlovsk Reg.Clin.Hosp.No.1

Yekaterinburg, , Russia

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Clinical Center of Serbia

Belgrade, , Serbia

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Special Hosp.for Cerebrovascul.Disease,'Sveti Sava,Belgrade

Belgrade, , Serbia

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Clinical Centre Nis

Niš, , Serbia

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Clinical Center of Vojvodina

Novi Sad, , Serbia

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National University Hospital

Singapore, , Singapore

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Singapore General Hospital

Singapore, , Singapore

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National Neuroscience Institute

Singapore, , Singapore

Site Status

Faculty Hospital L. Pasteura, Kosice

Košice, , Slovakia

Site Status

Faculty Hospital Nitra

Nitra, , Slovakia

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Instit.f.applicative Research in med.rehab.Dobrna

Dobrna, , Slovenia

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Cardial d.o.o., Specialist out-patient unit, Ljubljana

Ljubljana, , Slovenia

Site Status

Univ. Medical Center Maribor

Maribor, , Slovenia

Site Status

University of Pretoria

Pretoria, , South Africa

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Dr. Moodley and Dr. Sarvan

Tongaat, , South Africa

Site Status

Hallym University Sacred Heart Hospital

Anyang, , South Korea

Site Status

Dong-A University Hospital

Busan, , South Korea

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Kyungpook National Univ. Hosp

Daegu, , South Korea

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Chungnam National University Hospital

Daejoen, , South Korea

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Inje University Ilsan Paik Hospital

Goyang, , South Korea

Site Status

Chonnam National University Hospital

Gwangju, , South Korea

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Chosun University Hospital

Gwangju, , South Korea

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Seoul National University Bundang Hospital

Seongnam, , South Korea

Site Status

Severance Hospital

Seoul, , South Korea

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Asan Medical Center

Seoul, , South Korea

Site Status

The Catholic University of Korea, Seoul St.Mary's Hospital

Seoul, , South Korea

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Chung-Ang University Hospital

Seoul, , South Korea

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Korea University Guro Hospital

Seoul, , South Korea

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Kangdong Sacred Heart Hospital

Seoul, , South Korea

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Samsung Medical Center

Seoul, , South Korea

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SMG-SNU Boramae Medical Center

Seoul, , South Korea

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Ajou University Hospital

Suwon, , South Korea

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Hospital General Universitario de Albacete

Albacete, , Spain

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Hospital del Mar

Barcelona, , Spain

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Hospital Santa Creu i Sant Pau

Barcelona, , Spain

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Hospital Vall d'Hebron

Barcelona, , Spain

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Hospital Universitario Donostia

Donostia / San Sebastian, , Spain

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Hospital Universitari de Girona Doctor Josep Trueta

Girona, , Spain

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Hospital Arnau de Vilanova

Lleida, , Spain

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Hospital La Princesa

Madrid, , Spain

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Hospital General Universitario Gregorio Marañón

Madrid, , Spain

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Hospital Ramón y Cajal

Madrid, , Spain

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Hospital Clínico San Carlos

Madrid, , Spain

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Hospital La Paz

Madrid, , Spain

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Hospital Son Espases

Palma de Mallorca, , Spain

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Complejo Hospitalario de Navarra

Pamplona, , Spain

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Hospital Clínico de Santiago

Santiago de Compostela, , Spain

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Hospital Virgen del Rocío

Seville, , Spain

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Hospital Universitari Joan XXIII

Tarragona, , Spain

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Hospital Mútua Terrassa

Tarrasa (Barcelona), , Spain

Site Status

Hospital Clínico de Valencia

Valencia, , Spain

Site Status

Hospital Clínico Universitario de Valladolid

Valladolid, , Spain

Site Status

Sahlgrenska US, Göteborg

Gothenburg, , Sweden

Site Status

Sahlgrenska Universitetssjukhuset, Östra

Gothenburg, , Sweden

Site Status

Skaraborgs Sjukhus

Skövde, , Sweden

Site Status

Karolinska Univ. sjukhuset

Stockholm, , Sweden

Site Status

Karolinska Univ. sjukhuset

Stockholm, , Sweden

Site Status

Danderyds Sjukhus

Stockholm, , Sweden

Site Status

Canton Hospital Aarau, Neurology Dept., Stroke Center

Aarau, , Switzerland

Site Status

University Hospital Basel

Basel, , Switzerland

Site Status

Univ. Hospital Bern, Neurology Dept, Stroke Center

Bern, , Switzerland

Site Status

CHUV - Centre hospitalier universitaire vaudois

Lausanne, , Switzerland

Site Status

Regional Hospital Lugano,Neurocenter of Southern Switzerland

Lugano, , Switzerland

Site Status

Kantonsspital St.Gallen

Sankt Gallen, , Switzerland

Site Status

University Hosp. Zürich, Dept. of Neurology, Stroke Center

Zurich, , Switzerland

Site Status

Chang-Hua Christian Hospital

Changhua, , Taiwan

Site Status

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

Site Status

Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status

NCKUH

Tainan City, , Taiwan

Site Status

Chi Mei Medical Center

Tainan City, , Taiwan

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National Taiwan University Hospital

Taipei, , Taiwan

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Mackay Memorial Hospital

Taipei, , Taiwan

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Cheng Hsin General Hospital

Taipei, , Taiwan

Site Status

Taipe Veterans General Hospital

Taipei, , Taiwan

Site Status

Tri-Service General Hospital

Taipei, , Taiwan

Site Status

Chang Gung Memorial Hospital(TaoYuan)

Taoyuan District, , Taiwan

Site Status

Chulalongkorn University

Bangkok, , Thailand

Site Status

Ramathibodi Hospital

Bangkok, , Thailand

Site Status

Siriraj Hospital

Bangkok, , Thailand

Site Status

Lampang Hospital

Lampang, , Thailand

Site Status

Ankara Universitesi Tip Fakultesi

Ankara, , Turkey (Türkiye)

Site Status

Hacettepe Universitesi Tip Fakultesi Noroloji A.B.D.

Ankara, , Turkey (Türkiye)

Site Status

Gazi Universitesi Tip Fakultesi

Ankara, , Turkey (Türkiye)

Site Status

Eskisehir Osmangazi Universitesi Tip Fakultesi

Eskişehir, , Turkey (Türkiye)

Site Status

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Istanbul Universitesi Istanbul Tip Fakultesi Noroloji A.B.D.

Istanbul, , Turkey (Türkiye)

Site Status

Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, , Turkey (Türkiye)

Site Status

Bakirkoy Prof. Dr. Mazhar Osman Ruh Sagligi ve Sinir Hastaliklari

Istanbul, , Turkey (Türkiye)

Site Status

Bakırkoy Dr. Sadi Konuk Egitim Ve Arastirma Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Dokuz Eylul Universitesi Tip Fakultesi Noroloji A.B.D.

Izmir, , Turkey (Türkiye)

Site Status

Ondokuz Mayis Universitesi Tip Fakultesi

Samsun, , Turkey (Türkiye)

Site Status

Namik Kemal Universitesi Tip Fakultesi

Tekirdağ, , Turkey (Türkiye)

Site Status

Bukovinian Med.Univ.Chernivtsi Reg.Psychiatric Hosp,Neurolog

Chernivtsi, , Ukraine

Site Status

City Clinical Hospital No. 7, Kharkov

Kharkiv, , Ukraine

Site Status

Instit.of Neurol,Psychiatry&Narcol,Vascul. Malformations Dep

Kharkiv, , Ukraine

Site Status

Instit.of Gerontology na D.F.Chebotarev,Brain Vascular Path.

Kyiv, , Ukraine

Site Status

Lviv Regional Clinical Hospital, Lviv

Lviv, , Ukraine

Site Status

Ternopil State Med.Univ.na Gorbachevskiy,Neurology Dept N3

Ternopil, , Ukraine

Site Status

Vinnitsia Reg.Psychoneurol.Hosp.na Yushchenko,Dept.N3,Neurol

Vinnitsia, , Ukraine

Site Status

Zhytomyr Reg.ClinHosp na Gerbachevskiy RegCouncil,Neurol.Dep

Zhytomyr, , Ukraine

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References

Explore related publications, articles, or registry entries linked to this study.

Del Brutto VJ, Diener HC, Easton JD, Granger CB, Cronin L, Kleine E, Grauer C, Brueckmann M, Toyoda K, Schellinger PD, Lyrer P, Molina CA, Chutinet A, Bladin CF, Estol CJ, Sacco RL. Predictors of Recurrent Stroke After Embolic Stroke of Undetermined Source in the RE-SPECT ESUS Trial. J Am Heart Assoc. 2022 Jun 7;11(11):e023545. doi: 10.1161/JAHA.121.023545. Epub 2022 Jun 3.

Reference Type DERIVED
PMID: 35656979 (View on PubMed)

Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10.

Reference Type DERIVED
PMID: 35538232 (View on PubMed)

Bahit MC, Sacco RL, Easton JD, Meyerhoff J, Cronin L, Kleine E, Grauer C, Brueckmann M, Diener HC, Lopes RD, Brainin M, Lyrer P, Wachter R, Segura T, Granger CB; RE-SPECT ESUS Steering Committee and Investigators. Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source: An Analysis of the RE-SPECT ESUS Trial. Circulation. 2021 Nov 30;144(22):1738-1746. doi: 10.1161/CIRCULATIONAHA.121.055176. Epub 2021 Oct 15.

Reference Type DERIVED
PMID: 34649459 (View on PubMed)

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Diener HC, Chutinet A, Easton JD, Granger CB, Kleine E, Marquardt L, Meyerhoff J, Zini A, Sacco RL. Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS. Stroke. 2021 Mar;52(3):1065-1068. doi: 10.1161/STROKEAHA.120.031237. Epub 2021 Jan 28.

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Diener HC, Sacco RL, Easton JD, Granger CB, Bar M, Bernstein RA, Brainin M, Brueckmann M, Cronin L, Donnan G, Gdovinova Z, Grauer C, Kleine E, Kleinig TJ, Lyrer P, Martins S, Meyerhoff J, Milling T, Pfeilschifter W, Poli S, Reif M, Rose DZ, Sanak D, Schabitz WR. Antithrombotic Treatment of Embolic Stroke of Undetermined Source: RE-SPECT ESUS Elderly and Renally Impaired Subgroups. Stroke. 2020 Jun;51(6):1758-1765. doi: 10.1161/STROKEAHA.119.028643. Epub 2020 May 14.

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Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S, Kreuzer J, Cronin L, Cotton D, Grauer C, Brueckmann M, Chernyatina M, Donnan G, Ferro JM, Grond M, Kallmunzer B, Krupinski J, Lee BC, Lemmens R, Masjuan J, Odinak M, Saver JL, Schellinger PD, Toni D, Toyoda K; RE-SPECT ESUS Steering Committee and Investigators. Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. N Engl J Med. 2019 May 16;380(20):1906-1917. doi: 10.1056/NEJMoa1813959.

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Provided Documents

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Document Type: Statistical Analysis Plan

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Document Type: Study Protocol

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Other Identifiers

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2013-003444-24

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1160.189

Identifier Type: -

Identifier Source: org_study_id

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