Cerebral Oxygenation in Septic Patients Using Vasopressors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2017-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator

NCT06426407

Shock, Septic

RECRUITING

Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock

NCT03014063

Septic Shock

COMPLETED

Angiotensin II vs. Vasopressin in Septic Shock

NCT05193370

Septic Shock

WITHDRAWN PHASE4

Hemodynamic Effects of Vasopressin in Early Septic Shock Stage

NCT02053675

Septic Shock

COMPLETED NA

Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication

NCT07255378

Septic Shock

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The mortality with septic shock is high. Treatment includes antibiotics, intravenous fluid and drugs for circulatory support, especially the vasopressor norepinephrine. Fluids and drugs for circulatory support are to restore adequate organ perfusion. Inadequate oxygenation of the brain can give neurologic damage. Traditionally treatment is guided by surrogate markers like arterial and central venous pressure. Cerebral oximetry is a non-invasive method which measures cerebral saturation of oxygen, SCO2, and thereby expresses regional cerebral perfusion. By registering cerebral oxymetry on patients treated with vasopressors for septic shock we want to reveal if higher doses of vasopressor correlates with cerebral vasoconstriction and lower cerebral oximetry.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Septic Shock

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Septic shock and vasopressor

Measuring cerebral oxymetry (SCO2) first 24 hours in septic shock and given vasopressors.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 years or older
* Septic shock patients in ICU department requiring vasopressor therapy

Exclusion Criteria

* Damage to the frontal lobes corresponding to the area where SCO2 is monitored
* Patients in pharmacological studies
* Patients with known intracranial vascular anomalies or cerebral aneurysms
* Patients where vasoactive medication is started before cerebral oxymetry is established
* Patients with known neurological disease
* Patients with undergone cerebral insult, transient ischemic attack or carotid stenosis
* Patients who have been resuscitated after cardiac arrest in connection with this hospital stay
* Patients with a body temperature below 35 degrees Celsius when establishing monitoring

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No