Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2018-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study investigates wether patients with increased trigeminal perception threshold and low expression of TRP channels have more often nasal blockage despite functionally successful nasal surgery (TRP channel = transient receptor potential channel).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Endoscopic Versus Conventional Septoplasty in Treatment of Deviated Nasal Septum

NCT03666130

Endoscopic Septoplasty

UNKNOWN NA

Subjective and Objective Outcome of ESS in CRSwNP

NCT04868695

CRS

RECRUITING NA

Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis

NCT02784262

Chronic Disease Nasal Polyposis Rhinitis

COMPLETED PHASE2

Immediate Effect of Proponent-Nasal-Spray on Unspecific Discomfort in the Nose

NCT03251066

Unspecified Disorder of Nose and Nasal Sinuses

COMPLETED NA

Subjective and Objective Outcome of Septoplasty With or Without Infundibulotomy

NCT05698940

Nasal Blockage Nasal Obstruction Septum; Deviation

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The aim of this study is to find out wether patients with high trigeminal perception threshold (=decreased intranasal sensibility) and low expression of TRP channels of the mucosa suffer more often from impaired nasal breathing after surgery. This could lead to the identification of prognostic factors and therefore prevention of nasal surgery with bad outcome.

Further, differences between patients with empty nose syndrome and asymptomatic patients after extended intranasal surgery, concerning trigeminal perception and TRP channel expression will be investigated.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Empty Nose Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients receiving nose surgery

Patients in need of nose surgery, before and after surgery; or only after successful surgery, then with or without "Empty Nose Syndrome".

Group Type EXPERIMENTAL

Nasal surgery

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Nasal surgery

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Septoplasty Turbinoplasty Removal of turbinates and septum parts

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients undergoing a primary septoplasty and/or turbinoplasty
* Patients suffering from empty nose syndrome after measurably successful nasal surgery
* Patients with removed turbinates and/or septum, not suffering from ENS (i.e. tumor patients)

Exclusion Criteria

* Patients with known neurologic disorders that could compromise perception threshold measurements
* Patients with known allergies/intolerance to test agents that are used to measure perception thresholds (Cineol=Eucalypt; Menthol, CO2= Carbon Dioxide)
* Inability to judge or understand the testing or the informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No