Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

NCT ID: NCT02224586

Last Updated: 2014-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-31

Study Completion Date

2015-07-31

Brief Summary

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It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation(ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Detailed Description

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resting state fMRI scan light therapy the second time resting state fMRI scan

Conditions

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Jaundice

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

PROSPECTIVE

Study Groups

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light treatment

clinical routine treatment according to the doctor's advice

light treatment

Intervention Type DEVICE

clinical routine treatment according to the doctor's advice

Interventions

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light treatment

clinical routine treatment according to the doctor's advice

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* hyperbilirubinemia

Exclusion Criteria

* asphyxia
* cerebral dysgenesis
Minimum Eligible Age

1 Day

Maximum Eligible Age

28 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hangzhou Normal University

OTHER

Sponsor Role lead

Responsible Party

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Ya-Fei Zhu

chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ya-Fei Zhu

Role: PRINCIPAL_INVESTIGATOR

Center for Cognition and Brain Disorders,Hangzhou Normal University

Locations

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Center for Cognition and Brain Disorders

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiao-Bao Xue

Role: CONTACT

Facility Contacts

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Xiao-Bao Xue

Role: primary

Other Identifiers

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HNU_AH_jaundice fMRI

Identifier Type: -

Identifier Source: org_study_id

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