Comparison of Postprandial Glucose Control Associated With BIOD-531 vs. Humalog Mix 75/25 vs. Humulin R U-500

NCT ID: NCT02212951

Last Updated: 2016-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is to compare meal time glucose control associated with BIOD-531, a rapidly absorbed concentrated insulin to that associated with Humalog Mix 75/25 and Humulin R U-500.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Type 2 Diabetes Mellitus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

BIOD-531 pre-meal

Subcutaneous injection of 0.6 U/kg immediately before the start of the standardized breakfast

Group Type EXPERIMENTAL

BIOD-531

Intervention Type DRUG

Humalog Mix 75/25 pre-meal

Subcutaneous injection of 0.6 U/kg immediately before the start of the standardized breakfast

Group Type ACTIVE_COMPARATOR

Humalog Mix 75/25

Intervention Type DRUG

Humulin R U-500

Subcutaneous injection of 0.6 U/kg immediately before the start of a standardized breakfast

Group Type ACTIVE_COMPARATOR

Humulin R U-500

Intervention Type DRUG

BIOD-531 post-meal

Subcutaneous injection of 0.6 U/kg 20 minutes after the start of the standardized breakfast

Group Type EXPERIMENTAL

BIOD-531

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

BIOD-531

Intervention Type DRUG

Humalog Mix 75/25

Intervention Type DRUG

Humulin R U-500

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 18-65
* BMI \> 25 kg/m2
* Type 2 Diabetes Mellitus
* HbA1c \< 10.0%
* Subject uses 50-200 units of insulin/day

Exclusion Criteria

* Type 1 Diabetes Mellitus
* History of bariatric surgery
* Corticosteroid therapy
* Significant cardiovascular or other major organ disease
* Females who are breast feeding or pregnant
* A sexually active person not using adequate contraceptive methods
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Biodel

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Profil Institute for Clinical Research

Chula Vista, California, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

3-152

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.