Pharmacokinetic and Injection Site Toleration of BIOD-238 and BIOD-250 Compared to Humalog® in Subjects With Type 1 Diabetes

NCT ID: NCT01811849

Last Updated: 2013-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2012-12-31

Brief Summary

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A Double-blind Study of the Pharmacokinetic Properties of BIOD-238 and BIOD-250 Compared to Humalog® in Subjects with Type 1 Diabetes

Detailed Description

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The purpose of this study is to assess the speed of absorption of BIOD-238 and BIOD-250 compared to Humalog®. Secondary objectives are to assess other pharmacokinetic characteristics of BIOD-238 and BIOD-250 compared to Humalog®, and to evaluate the safety and tolerability of BIOD-238 and BIOD-250 compared to Humalog®.

Conditions

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Type 1 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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BIOD-238

Subcutaneous injection

Group Type EXPERIMENTAL

Insulin LISPRO

Intervention Type DRUG

BIOD-250

Subcutaneous injection

Group Type EXPERIMENTAL

Insulin LISPRO

Intervention Type DRUG

Humalog

Subcutaneous injection

Group Type ACTIVE_COMPARATOR

Insulin LISPRO

Intervention Type DRUG

Interventions

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Insulin LISPRO

Intervention Type DRUG

Insulin LISPRO

Intervention Type DRUG

Insulin LISPRO

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age: ≥18 to ≤70 years
* Body Mass Index: ≥18 and ≤35 kg/m2
* Diagnosed with Type 1 Diabetes Mellitus for at least 1 year

Exclusion Criteria

* Type 2 diabetes mellitus
* Serum C-peptide \>1.0 ng/mL
* HbA1c \>10.0%
* History of hypersensitivity to any of the components in the study medication
* Treatment with any other investigational drug in the last 30 days before dosing.
* Current drug or alcohol abuse, or a history of drug or alcohol abuse which in the opinion of the Investigator will impair subject safety, protocol compliance, or interpretation of study results. Caffeine, nicotine or alcohol addiction which might be expected to result in withdrawal symptoms during the course of a study dosing day would fall into this category.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biodel

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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4-102

Identifier Type: -

Identifier Source: org_study_id

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