Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine

NCT ID: NCT02206178

Last Updated: 2016-07-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2014-01-31

Brief Summary

Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain.

The purpose of this study is to assess the effectiveness of acetaminophen in association with N-acetylcysteine.

The objective of this study is to evaluate if the association in healthy volunteers of acetaminophen and N-acétylcystéine

1. - decrease the antinociceptive effect of acetaminophen in comparison to a group control

2. - and if this antinociceptive effect may depend of the genetic polymorphism of GSH enzyme.

Detailed Description

Period 1 : To Day -4 to Day 0

Day -4 at 8:00 am at Clinical Pharmacology Center

• Inclusion Visit, signature of Informed consent form, clinical exam.
• Training test
• Blood sample (GSH, pharmacogenetic, Biochemistry assay)
• Randomization and attribution of treatment for the fisrt study period at home: (day -4, -3, -2, -1) 4 days of oral acetaminophen and [N-acetylcysteine or placebo] according to the randomization plan.

At day -3, -2 and -1 a salivary sample will be done to control the treatment compliance.

Day 0 at Clinical Pharmacology Center Clinical examination Measurement of the basal pain thresholds and pain evaluation (Visual Analog Scales) Blood and urinary sample (acetaminophen and GSH assay)

T0 : Administration of product: acetaminophen and [N-acetylcysteine or placebo]

T0+1H: Thermal stimulation according to the established paradigm (threshold temperature +3°C ) and pain evaluation (Visual Analog Scales)

T0+2H: Thermal stimulation according to the established paradigm (threshold temperature +3°C ) and pain evaluation (Visual Analog Scales) and Blood sample (acetaminophen assay)

T0+3H: Thermal stimulation according to the established paradigm (threshold temperature +3°C ) and pain evaluation (Visual Analog Scales)

T0+4H: Thermal stimulation according to the established paradigm (threshold temperature +3°C ) and pain evaluation (Visual Analog Scales) and Blood and urinary sample (acetaminophen, GSH, biochemistry assay)

• Lunch before departure

2 weeks of wash-out

Period 2 : To Day 17 to Day 21

Same of period 1. Subject who receives N-acétylcystéine in period 1 will receive placebo in second period and vice versa.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

acetaminophen

The purpose of this study is to assess the effectiveness of acetaminophen in association with N-acetylcysteine.

The objective of this study is to evaluate if the association in healthy volunteers of acetaminophen and N-acétylcystéine

1. - decrease the antinociceptive effect of acetaminophen in comparison to a group control

2. - and if this antinociceptive effect may depend of the genetic polymorphism of GSH enzyme

Group Type: EXPERIMENTAL

N-acetylcysteine combination with acetaminophen

Intervention Type: DRUG

placebo

1. - decrease the antinociceptive effect of acetaminophen in comparison to a group control

2. - and if this antinociceptive effect may depend of the genetic polymorphism of GSH enzyme

Group Type: PLACEBO_COMPARATOR

N-acetylcysteine combination with acetaminophen

Intervention Type: DRUG

Placebo

Intervention Type: DRUG

Interventions

N-acetylcysteine combination with acetaminophen

Intervention Type: DRUG

Placebo

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Male
• Between 18 and 45 years old
• Without treatment during the 7 days before inclusion specially no use of antalgic and anti-inflammatory
• Cooperation and understanding enough to conform to the study obligations -Having given free, informed written consent
• Affiliated at system of French social security
• Inscription or acceptation of inscription in the national register of volunteers involved in trials.

Exclusion Criteria

• Patient with one or many contraindication for the administration of the trial's products,
• Patient that have taken N-acetylcysteine as bronchial thinner during the last 3 days,
• Patient with medical or surgical history judged by the investigator or his representative as being not compatible with the clinical trial
• Patient with disease progression during inclusion,
• Patient with excessive consumption of alcohol, tobacco (+ than 10 cigarette/day), coffee, tea or drinks with caffeine (equivalent to more than 4 cup a day) or any addiction to drugs,
• Patient with a heat pain mean threshold during training higher or equal to 46.5°C,
• Patient who participated in another clinical trial, located in exclusion period or received benefits > 4500 euros during 12 months before the beginning of trial,
• Patient with cooperation and understanding that do not allow him to follow the trial,
• Patients with minor or under guardianship,
• No affiliation at system of French social security

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gisèle PICKERING

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Clermont-Ferrand

Locations

CHU de Clermont-Ferrand

Clermont-Ferrand, , France

Countries

France

Other Identifiers

2013-000668-27

Identifier Type: -

Identifier Source: secondary_id

CHU-0202

Identifier Type: -

Identifier Source: org_study_id