Prehospital Management of Stroke Patients by Emergency Medical Services
NCT ID: NCT02191514
Last Updated: 2016-01-05
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Total Enrollment
2653 participants
Study Classification
OBSERVATIONAL
Study Start Date
2014-07-31
Study Completion Date
2015-05-31
Brief Summary
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Annually 12.000 people i Denmark suffer from a stroke. Treatment for ischemic stroke is available, but only 12% of stroke patients receive it.
The treatment is only available within a time frame of 4,5 hours from symptom onset, thus the Emergency Medical Services (EMS) is essential to fast and effective stroke treatment.
The aim of this study is:
1. To establish the rate of recognition of stroke symptoms by healthcare personnel in the EMD, ultimately aiming at optimizing performance, and identifying barriers for a fast and correct EMS-response.
2. To assess prehospital time consumption by ambulance personnel on the scene of a stroke, create a baseline for future comparison and generate explorative hypotheses for forthcoming interventions.
The overall aim of this study is, to ensure the best possible prehospital care for all stroke patients. The study will determine, if the EMD is at a high and international level in regards to stroke recognition, and if there is a potential to decrease on-scene time. This will serve as future comparison and have an effect on the structure and future education in the prehospital services, and potentially improve the outcome after acute ischemic stroke.
The treatment is only available within a time frame of 4,5 hours from symptom onset, thus the Emergency Medical Services (EMS) is essential to fast and effective stroke treatment.
The aim of this study is:
1. To establish the rate of recognition of stroke symptoms by healthcare personnel in the EMD, ultimately aiming at optimizing performance, and identifying barriers for a fast and correct EMS-response.
2. To assess prehospital time consumption by ambulance personnel on the scene of a stroke, create a baseline for future comparison and generate explorative hypotheses for forthcoming interventions.
The overall aim of this study is, to ensure the best possible prehospital care for all stroke patients. The study will determine, if the EMD is at a high and international level in regards to stroke recognition, and if there is a potential to decrease on-scene time. This will serve as future comparison and have an effect on the structure and future education in the prehospital services, and potentially improve the outcome after acute ischemic stroke.
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Detailed Description
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Background:
Approximately 12.000 strokes occur in Denmark annually. The only evidence based pharmacological treatment of ischemic stroke is thrombolysis within a time-window of 4.5 hours from symptom onset(1). In 2012, 12% of patients with ischemic stroke in Denmark received thrombolysis treatment. The probability of a favourable 3-month outcome after stroke decreases with time from symptom onset to thrombolysis: the onset to needle time(2). Therefore, it is of the highest importance to identify potential targets for prehospital time reduction, and thereby reduce delay to definitive care.
Prompt recognition of stroke symptoms by both the EMD and ambulance personnel is a crucial step, as it provides access to fast track acute stroke services. In this context, the role of the EMS is essential, as contact to the hospital through EMS opposed to private transport is correlated to decreased onset-to-door time (3). EMS prenotification of the stroke centre is correlated to shorter door-to-evaluation time, door-to-needle time and onset-to-needle time(4). In Denmark EMS prenotification in acute stroke is well established.
According to Danish guidelines for treatment of acute stroke and transient ischaemic attack (TIA), prehospital diagnosis of stroke is improved by use of validated tests. No such is yet implemented in the Capital Region of Denmark.
Preliminary data shows that the mean time from the ambulance personnel arrives at the scene to they start the transport to the hospital ("on scene time") is 18 minutes in the Capital Region of Denmark. American guidelines suggest that on-scene-time should be less than 15 minutes in all cases (unless extenuating circumstances or extrication difficulties are present)(1), however the organisation of stroke care between Scandinavia and USA varies largely.
The aim of this study is:
1. To establish the rate of recognition of stroke symptoms by healthcare personnel in the EMD, ultimately aiming at optimizing performance, and identifying barriers for a fast and correct EMS-response.
2. To assess prehospital time consumption by ambulance personnel on the scene of a stroke, create a baseline for future comparison and generate explorative hypotheses for forthcoming interventions.
The study consists of 3 arms:
1. An epidemiological analysis of prospectively collected data from a 2-year period, in order to establish the rate of identification of stroke symptoms by healthcare personnel in the EMD.
2. A quantification and statistical analysis of on-scene-time in stroke patients, based on prospectively collected data from a registration form filled out by the ambulance personnel after responding to a stroke. The focus of the form is on time spent on predefined tasks aiming at assessing time consumption on the scene, and generating explorative hypotheses for forthcoming interventions.
3. Based on EMS data, the investigators will establish a baseline for on-scene-time and transportation time in patients admitted by fast track stroke service during a 6 months period, for future comparison and analyse data in conjunction with in-hospital delays.
Method for each arm:
1. The epidemiological analysis is based on prospectively collected data from the Danish Stroke Registry (DSR) and the National Patient Registry (NPR). In the DSR and NPR, ICD-10-codes are linked to the Danish personal identification number, a unique number for every Danish citizen. The investigators shall compare ICD-10 codes from DSR and NPR with dispatch codes from the EMS database, to determine the amount of diagnosed stroke patients recognized during the emergency call. The date of the incident report from the EMS will be matched with the admission date correlated to the discharge ICD-10 code, in case a patient has been admitted more than once.
2. To quantify and analyse prehospital time consumption, the investigators will develop a registration form for the ambulance personnel to fill out after responding to a stroke patient.
This registration form will include registration of time intervals spent on:
* Clinical tasks; including prior medical history, clinical examination and measurement of vital parameters
* Communication in relation to prenotification of the stroke centre
* Mobilization of the patient and on-scene conditions
* Patient preparation; including IV-accesses and 12-lead ECG
As well as information regarding:
* Patient preparation; including IV-accesses and 12-lead ECG
* Language/communication barriers
* Specifications of the ambulance (operator, level of education)
* Patient/relative related conditions
* Visitation to acute stroke fast track
Statistical analyses:
Poisson regression analyses will be made with over dispersion taken into account, in order to identify specific time intervals and tasks correlated to extended or decreased total on-scene-time. This model yields distributions similar to previously collected data.
A power calculation has been made, based on this distribution and the assumption that a clinically relevant difference, is defined as any time interval in cases considered as having a high on-scene-time, (\>15 min.) being twice the amount than in cases considered as having a low on-scene-time (≤15 min.). This has shown an estimated demand of 500 registration forms in order to achieve a power of 0,8 with a 5% two-sided confidence interval.
3. The establishment of on-scene-times and transportation-times will be made by extracting specific time points (e.g. ambulance arrival at the scene, departure towards hospital and arrival at hospital) from the EMS database during a 6 months period, and analysed in conjunction with data on in-hospital delays.
The stroke centres will provide Danish personal identification numbers for patients referred to the stroke centres as well as door-to-needle times and treatment decisions in order to determine if there is a correlation be-tween recognition and treatment decisions in stroke fast track patients.
As there is no prior comparable registration of this, it is impossible to estimate a clinically relevant difference in order to make a power calculation and determine the amount of necessary registrations. Thus it has been decided that a 6-month registration will provide a reliable baseline. To avoid bias, the registration of this variable, will start after the end of the registration form period.
The overall aim of this study is, to ensure the best possible prehospital care for all stroke patients. The study will determine, if the EMD is at a high and international level in regards to stroke recognition, and if there is a potential to decrease on-scene time. This will serve as future comparison and have an effect on the structure and future education in the prehospital services, and potentially improve the outcome after acute ischemic stroke.
Distribution of responsibilities:
Søren Viereck; Medical student, University of Copenhagen; research employee/project manager: Literature search data analysis, development and evaluation of registration form for ambulance personnel, first draft of paper (planned 1. author) and fundraising.
Thea Palsgaard Møller; MD; Research fellow, Emergency Medical Services Copenhagen: Data extraction and supervision on data analysis, critical review of results.
Karl Bang Christensen: Associate Professor, Department of Biostatistics, University of Copenhagen: Critical review of protocol, supervision on statistical analyses, critical review of results.
Hanne Christensen; Senior Stroke Neurologist \& Associate Professor, MD, PhD, DMSci, Department of Neurology, Bispebjerg Hospital, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results
Helle Klingenberg Iversen, MD, Senior Stroke Neurologist \& associate professor Department of Neurology, Glostrup Hospital, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results.
Freddy Lippert; CEO, Emergency Medical Services in the Capital Region of Denmark; Associate professor, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results and overall clinical and scientific responsibility,
Approximately 12.000 strokes occur in Denmark annually. The only evidence based pharmacological treatment of ischemic stroke is thrombolysis within a time-window of 4.5 hours from symptom onset(1). In 2012, 12% of patients with ischemic stroke in Denmark received thrombolysis treatment. The probability of a favourable 3-month outcome after stroke decreases with time from symptom onset to thrombolysis: the onset to needle time(2). Therefore, it is of the highest importance to identify potential targets for prehospital time reduction, and thereby reduce delay to definitive care.
Prompt recognition of stroke symptoms by both the EMD and ambulance personnel is a crucial step, as it provides access to fast track acute stroke services. In this context, the role of the EMS is essential, as contact to the hospital through EMS opposed to private transport is correlated to decreased onset-to-door time (3). EMS prenotification of the stroke centre is correlated to shorter door-to-evaluation time, door-to-needle time and onset-to-needle time(4). In Denmark EMS prenotification in acute stroke is well established.
According to Danish guidelines for treatment of acute stroke and transient ischaemic attack (TIA), prehospital diagnosis of stroke is improved by use of validated tests. No such is yet implemented in the Capital Region of Denmark.
Preliminary data shows that the mean time from the ambulance personnel arrives at the scene to they start the transport to the hospital ("on scene time") is 18 minutes in the Capital Region of Denmark. American guidelines suggest that on-scene-time should be less than 15 minutes in all cases (unless extenuating circumstances or extrication difficulties are present)(1), however the organisation of stroke care between Scandinavia and USA varies largely.
The aim of this study is:
1. To establish the rate of recognition of stroke symptoms by healthcare personnel in the EMD, ultimately aiming at optimizing performance, and identifying barriers for a fast and correct EMS-response.
2. To assess prehospital time consumption by ambulance personnel on the scene of a stroke, create a baseline for future comparison and generate explorative hypotheses for forthcoming interventions.
The study consists of 3 arms:
1. An epidemiological analysis of prospectively collected data from a 2-year period, in order to establish the rate of identification of stroke symptoms by healthcare personnel in the EMD.
2. A quantification and statistical analysis of on-scene-time in stroke patients, based on prospectively collected data from a registration form filled out by the ambulance personnel after responding to a stroke. The focus of the form is on time spent on predefined tasks aiming at assessing time consumption on the scene, and generating explorative hypotheses for forthcoming interventions.
3. Based on EMS data, the investigators will establish a baseline for on-scene-time and transportation time in patients admitted by fast track stroke service during a 6 months period, for future comparison and analyse data in conjunction with in-hospital delays.
Method for each arm:
1. The epidemiological analysis is based on prospectively collected data from the Danish Stroke Registry (DSR) and the National Patient Registry (NPR). In the DSR and NPR, ICD-10-codes are linked to the Danish personal identification number, a unique number for every Danish citizen. The investigators shall compare ICD-10 codes from DSR and NPR with dispatch codes from the EMS database, to determine the amount of diagnosed stroke patients recognized during the emergency call. The date of the incident report from the EMS will be matched with the admission date correlated to the discharge ICD-10 code, in case a patient has been admitted more than once.
2. To quantify and analyse prehospital time consumption, the investigators will develop a registration form for the ambulance personnel to fill out after responding to a stroke patient.
This registration form will include registration of time intervals spent on:
* Clinical tasks; including prior medical history, clinical examination and measurement of vital parameters
* Communication in relation to prenotification of the stroke centre
* Mobilization of the patient and on-scene conditions
* Patient preparation; including IV-accesses and 12-lead ECG
As well as information regarding:
* Patient preparation; including IV-accesses and 12-lead ECG
* Language/communication barriers
* Specifications of the ambulance (operator, level of education)
* Patient/relative related conditions
* Visitation to acute stroke fast track
Statistical analyses:
Poisson regression analyses will be made with over dispersion taken into account, in order to identify specific time intervals and tasks correlated to extended or decreased total on-scene-time. This model yields distributions similar to previously collected data.
A power calculation has been made, based on this distribution and the assumption that a clinically relevant difference, is defined as any time interval in cases considered as having a high on-scene-time, (\>15 min.) being twice the amount than in cases considered as having a low on-scene-time (≤15 min.). This has shown an estimated demand of 500 registration forms in order to achieve a power of 0,8 with a 5% two-sided confidence interval.
3. The establishment of on-scene-times and transportation-times will be made by extracting specific time points (e.g. ambulance arrival at the scene, departure towards hospital and arrival at hospital) from the EMS database during a 6 months period, and analysed in conjunction with data on in-hospital delays.
The stroke centres will provide Danish personal identification numbers for patients referred to the stroke centres as well as door-to-needle times and treatment decisions in order to determine if there is a correlation be-tween recognition and treatment decisions in stroke fast track patients.
As there is no prior comparable registration of this, it is impossible to estimate a clinically relevant difference in order to make a power calculation and determine the amount of necessary registrations. Thus it has been decided that a 6-month registration will provide a reliable baseline. To avoid bias, the registration of this variable, will start after the end of the registration form period.
The overall aim of this study is, to ensure the best possible prehospital care for all stroke patients. The study will determine, if the EMD is at a high and international level in regards to stroke recognition, and if there is a potential to decrease on-scene time. This will serve as future comparison and have an effect on the structure and future education in the prehospital services, and potentially improve the outcome after acute ischemic stroke.
Distribution of responsibilities:
Søren Viereck; Medical student, University of Copenhagen; research employee/project manager: Literature search data analysis, development and evaluation of registration form for ambulance personnel, first draft of paper (planned 1. author) and fundraising.
Thea Palsgaard Møller; MD; Research fellow, Emergency Medical Services Copenhagen: Data extraction and supervision on data analysis, critical review of results.
Karl Bang Christensen: Associate Professor, Department of Biostatistics, University of Copenhagen: Critical review of protocol, supervision on statistical analyses, critical review of results.
Hanne Christensen; Senior Stroke Neurologist \& Associate Professor, MD, PhD, DMSci, Department of Neurology, Bispebjerg Hospital, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results
Helle Klingenberg Iversen, MD, Senior Stroke Neurologist \& associate professor Department of Neurology, Glostrup Hospital, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results.
Freddy Lippert; CEO, Emergency Medical Services in the Capital Region of Denmark; Associate professor, University of Copenhagen: Supervision, critical review of protocol, provision of data, supervision of data-analysis, critical review of results and overall clinical and scientific responsibility,
Conditions
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Stroke
Study Design
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Observational Model Type
COHORT
Study Time Perspective
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* All patients are included if registered in Danish Stroke Registry with an ICD-10 code of stroke (haemorrhagic and ischemic - I61 and I63-64.9), in the National Patient Registry with an ICD-10 code of TIA (Transient Ischemic Attack - G45.9) or in the Emergency Medical Services-database with a dispatch code of suspected stroke (A.26.03, A.26.04) from the 2-year period 01-01-2012 - 12-31-2013.
* Patients with suspected stroke where the EMS has been in contact with fast track stroke service at the stroke centre are included.
* All patients with a Danish personal identification number, referred to one of the two regional stroke centres, during a 6-month period will be included. The 6 month period will begin after the above mentioned 500 registration form has been collected, to avoid bias.
* Patients with suspected stroke where the EMS has been in contact with fast track stroke service at the stroke centre are included.
* All patients with a Danish personal identification number, referred to one of the two regional stroke centres, during a 6-month period will be included. The 6 month period will begin after the above mentioned 500 registration form has been collected, to avoid bias.
Exclusion Criteria
* Patients are excluded if the Danish personal identification number is not available in either database. If the patient has been directly referred to the hospital by their general practitioner without the use of a EMS transport, or they have presented themselves in the emergency room, they will not be registered in the EMS database.
Part 2.
* Incomplete forms will be excluded.
Part 3.
* none
Part 2.
* Incomplete forms will be excluded.
Part 3.
* none
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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University of Copenhagen
OTHER
Sponsor Role
collaborator
Bispebjerg Hospital
OTHER
Sponsor Role
collaborator
Glostrup University Hospital, Copenhagen
OTHER
Sponsor Role
collaborator
TrygFonden, Denmark
INDUSTRY
Sponsor Role
collaborator
Emergency Medical Services, Capital Region, Denmark
OTHER_GOV
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Freddy Lippert, MD, CEO
Role: STUDY_DIRECTOR
Emergency Medical Services, Capital Region, Denmark
Locations
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EMS Copenhagen
Copenhagen, Ballerup, Denmark
Site Status
Countries
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Denmark
References
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Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013 Mar;44(3):870-947. doi: 10.1161/STR.0b013e318284056a. Epub 2013 Jan 31.
Reference Type
BACKGROUND
Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group; Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2010 May 15;375(9727):1695-703. doi: 10.1016/S0140-6736(10)60491-6.
Reference Type
BACKGROUND
Tong D, Reeves MJ, Hernandez AF, Zhao X, Olson DM, Fonarow GC, Schwamm LH, Smith EE. Times from symptom onset to hospital arrival in the Get with the Guidelines--Stroke Program 2002 to 2009: temporal trends and implications. Stroke. 2012 Jul;43(7):1912-7. doi: 10.1161/STROKEAHA.111.644963. Epub 2012 Apr 26.
Reference Type
BACKGROUND
Lin CB, Peterson ED, Smith EE, Saver JL, Liang L, Xian Y, Olson DM, Shah BR, Hernandez AF, Schwamm LH, Fonarow GC. Emergency medical service hospital prenotification is associated with improved evaluation and treatment of acute ischemic stroke. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):514-22. doi: 10.1161/CIRCOUTCOMES.112.965210. Epub 2012 Jul 10.
Reference Type
BACKGROUND
Drenck N, Viereck S, Baekgaard JS, Christensen KB, Lippert F, Folke F. Pre-hospital management of acute stroke patients eligible for thrombolysis - an evaluation of ambulance on-scene time. Scand J Trauma Resusc Emerg Med. 2019 Jan 9;27(1):3. doi: 10.1186/s13049-018-0580-4.
Reference Type
DERIVED
Viereck S, Moller TP, Iversen HK, Christensen H, Lippert F. Medical dispatchers recognise substantial amount of acute stroke during emergency calls. Scand J Trauma Resusc Emerg Med. 2016 Jul 7;24:89. doi: 10.1186/s13049-016-0277-5.
Reference Type
DERIVED
Other Identifiers
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EMS-2014-SV-01
Identifier Type: -
Identifier Source: org_study_id
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