A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers

NCT ID: NCT02174835

Last Updated: 2014-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2013-11-30

Brief Summary

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To assess the multiple-dose pharmacokinetics (PK), safety and tolerability of AVP-786 (deuterated \[d6\] dextromethorphan hydrobromide \[DM\]/quinidine sulfate \[Q\]) in healthy volunteers.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

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Cohort A - Period 1

Twice daily dosing orally for 7 days

Group Type EXPERIMENTAL

AVP-786

Intervention Type DRUG

Cohort A - Period 2

Twice daily dosing orally for 7 days

Group Type ACTIVE_COMPARATOR

AVP-923

Intervention Type DRUG

Cohort A - Period 3

Twice daily dosing orally for 7 days

Group Type EXPERIMENTAL

AVP-786

Intervention Type DRUG

Cohort B - Period 1

Twice daily dosing orally for 7 days

Group Type EXPERIMENTAL

AVP-786

Intervention Type DRUG

Cohort B - Period 2

Twice daily dosing orally for 7 days

Group Type ACTIVE_COMPARATOR

AVP-923

Intervention Type DRUG

Cohort B - Period 3

Twice daily dosing orally for 7 days

Group Type EXPERIMENTAL

AVP-786

Intervention Type DRUG

Interventions

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AVP-786

Intervention Type DRUG

AVP-923

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy adult males
* 18 - 45 years of age
* BMI 18 - 30 kg/m2

Exclusion Criteria

* History or presence of significant disease
* History of substance abuse and/or alcohol abuse with the past 3 years
* Use of tobacco-containing or nicotine-containing products within 6 months
* Use of any prescription or the over-the-counter medications within 14 days
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Avanir Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sepehr Shakib, M.D.

Role: PRINCIPAL_INVESTIGATOR

CMAX

Locations

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CMAX

Adelaide, South Australia, Australia

Site Status

Countries

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Australia

Other Identifiers

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13-AVR-134

Identifier Type: -

Identifier Source: org_study_id

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