Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy
NCT ID: NCT02168608
Last Updated: 2014-06-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2014-09-30
2016-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Remote ischemia precondition
patients in this arm accepted RIPC procedure after induction of anesthesia
Remote ischemia precondition
Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff placed on the right upper arm served as RIPC stimulus.
None remote ischemia precondition
patients in this arm didn't accept RIPC procedure after induction of anesthesia
None remote ischemia precondition
Placed an uninflated cuff on the right upper arm for 30 min.
Interventions
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Remote ischemia precondition
Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff placed on the right upper arm served as RIPC stimulus.
None remote ischemia precondition
Placed an uninflated cuff on the right upper arm for 30 min.
Eligibility Criteria
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Inclusion Criteria
* Selective hepatectomy, one time hepatic portal occlusion
* Child-Pugh A
Exclusion Criteria
* Not the same surgical procedure as expected
* Administered anti-inflammatory drugs as glucocorticoid etc
* Diagnosed of diabetes
* History of liver surgery
* History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy
* Refuse to join the research
* Patients with psychopathy
* Acute infection need antibiotic therapy
* Hepatic artery or portal vein embolism
18 Years
70 Years
ALL
No
Sponsors
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Eastern Hepatobiliary Surgery Hospital
OTHER
Responsible Party
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Wei-feng Yu
professor
Principal Investigators
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Weifeng Yu, professor
Role: STUDY_CHAIR
Eastern Hepatobiliary Surgery Hospital
Locations
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Eastern Hepatobiliary Surgery Hospital
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Kin H, Zhao ZQ, Sun HY, Wang NP, Corvera JS, Halkos ME, Kerendi F, Guyton RA, Vinten-Johansen J. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res. 2004 Apr 1;62(1):74-85. doi: 10.1016/j.cardiores.2004.01.006.
Huguet C, Addario-Chieco P, Gavelli A, Arrigo E, Harb J, Clement RR. Technique of hepatic vascular exclusion for extensive liver resection. Am J Surg. 1992 Jun;163(6):602-5. doi: 10.1016/0002-9610(92)90567-b.
Delva E, Camus Y, Nordlinger B, Hannoun L, Parc R, Deriaz H, Lienhart A, Huguet C. Vascular occlusions for liver resections. Operative management and tolerance to hepatic ischemia: 142 cases. Ann Surg. 1989 Feb;209(2):211-8. doi: 10.1097/00000658-198902000-00012.
Clavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg. 2000 Aug;232(2):155-62. doi: 10.1097/00000658-200008000-00001.
Azoulay D, Lucidi V, Andreani P, Maggi U, Sebagh M, Ichai P, Lemoine A, Adam R, Castaing D. Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study. J Am Coll Surg. 2006 Feb;202(2):203-11. doi: 10.1016/j.jamcollsurg.2005.10.021.
Other Identifiers
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EHBHKY2013-003-006
Identifier Type: -
Identifier Source: org_study_id
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