Risk of Diabetes in Young Turner Syndrome Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2017-06-30

Brief Summary

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Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.

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Detailed Description

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The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam

Conditions

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Turner Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Turner Syndrome

Female with Turner Syndrome

No interventions assigned to this group

Healthy Controls

Healthy Female

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Turner Syndrome confirmed by chromosomal testing
* On standard therapy (growth hormone and or estrogen)

* Healthy

Exclusion Criteria

* Type 1 or Type 2 diabetes
* Polycystic Ovarian Syndrome
* Pregnancy
* On any medications that alter blood sugar

Healthy Female Controls:

* Type 1 or Type 2 diabetes
* Polycystic Ovarian Syndrome
* Pregnancy
* On any medications that alter blood sugar

Minimum Eligible Age

6 Years

Maximum Eligible Age

22 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes