Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
30 participants
INTERVENTIONAL
2013-05-31
2013-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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PDT with blue light and curcumin
PDT treatment was performed with light and curcumin.The irradiation parameters were: blue-light emitting diode (LED) illumination (455±30 nm), 400 mW of average optical power, 5 min of application, illumination area of 0.666 cm2, 600 mW/cm2 of intensity and 120 J/cm2 of fluence. The curcumin concentration of 30 mg/L was used.
mouthwash with curcumin
Mouthwash with 20 ml of curcumin solution for 5 minutes
blue LED illumination
Oral cavity was illuminated with blue light for 5 minutes
Curcumin
The curcumin concentration of 30 mg/L was used.
mouthwash with curcumin
Mouthwash with 20 ml of curcumin solution for 5 minutes
Blue light
The irradiation parameters were: blue-light emitting diode (LED) illumination (455±30 nm), 400 mW of average optical power, 5 min of application, illumination area of 0.666 cm2, 600 mW/cm2 of intensity and 120 J/cm2 of fluence.
blue LED illumination
Oral cavity was illuminated with blue light for 5 minutes
Interventions
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mouthwash with curcumin
Mouthwash with 20 ml of curcumin solution for 5 minutes
blue LED illumination
Oral cavity was illuminated with blue light for 5 minutes
Eligibility Criteria
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Inclusion Criteria
* those who do not perform any oral hygiene, such as flossing, brushing and antiseptic mouthwash
* those who performed 12-hour fasting prior the treatment and measurements
Exclusion Criteria
* smoking habits
* pregnancy
* patients with partial or total dentures
* orthodontic brackets users
20 Years
35 Years
ALL
Yes
Sponsors
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
OTHER_GOV
Fundação de Amparo à Pesquisa do Estado de São Paulo
OTHER_GOV
University of Sao Paulo
OTHER
Responsible Party
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Fernanda Rossi Paolillo
Ph.D
Principal Investigators
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Vanderlei S Bagnato, Ph.D
Role: STUDY_DIRECTOR
Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
Diego PV Leite, DDS
Role: PRINCIPAL_INVESTIGATOR
Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
Fernanda R Paolillo, Ph.D
Role: PRINCIPAL_INVESTIGATOR
Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
Carla R Fontana, Ph.D
Role: PRINCIPAL_INVESTIGATOR
Univ Estadual Paulista (UNESP)
Thiago Parmesano, Student
Role: STUDY_CHAIR
Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
Locations
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Fernanda Rossi Paolillo
São Carlos, São Paulo, Brazil
Countries
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References
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Araujo NC, Fontana CR, Gerbi ME, Bagnato VS. Overall-mouth disinfection by photodynamic therapy using curcumin. Photomed Laser Surg. 2012 Feb;30(2):96-101. doi: 10.1089/pho.2011.3053. Epub 2012 Jan 6.
Araujo NC, Fontana CR, Bagnato VS, Gerbi ME. Photodynamic antimicrobial therapy of curcumin in biofilms and carious dentine. Lasers Med Sci. 2014 Mar;29(2):629-35. doi: 10.1007/s10103-013-1369-3. Epub 2013 Jun 23.
Gursoy H, Ozcakir-Tomruk C, Tanalp J, Yilmaz S. Photodynamic therapy in dentistry: a literature review. Clin Oral Investig. 2013 May;17(4):1113-25. doi: 10.1007/s00784-012-0845-7. Epub 2012 Sep 27.
Fontana CR, Lerman MA, Patel N, Grecco C, Costa CA, Amiji MM, Bagnato VS, Soukos NS. Safety assessment of oral photodynamic therapy in rats. Lasers Med Sci. 2013 Feb;28(2):479-86. doi: 10.1007/s10103-012-1091-6. Epub 2012 Mar 31.
Soukos NS, Som S, Abernethy AD, Ruggiero K, Dunham J, Lee C, Doukas AG, Goodson JM. Phototargeting oral black-pigmented bacteria. Antimicrob Agents Chemother. 2005 Apr;49(4):1391-6. doi: 10.1128/AAC.49.4.1391-1396.2005.
Related Links
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Optics and Photonics Research Center
Other Identifiers
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CNPQ2013
Identifier Type: -
Identifier Source: org_study_id
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