The Clinical Profile of UK Asthma Patients With Raised Blood Eosinophils

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

130248 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2014-07-31

Brief Summary

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To explore the relationship between blood eosinophil counts, asthma exacerbations and patient asthma control using a large primary care based research database

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Detailed Description

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Sputum eosinophil levels have been shown to predict asthma exacerbation and inhaled corticosteroid (ICS) responsivenesss. Managing asthma based on sputum eosinophils leads to fewer exacerbations than management adhering to Global Initiative for Asthma (GINA) guidelines. However the use of sputum to measure eosinophil levels is expensive and impractical within a clinical setting. This study explores the use of blood-eosinophil levels as a clinical predictor for exacerbations and asthma control within a UK primary care dataset.

Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Blood eosinophil count ≤ 400/µl

No interventions assigned to this group

Blood eosinophil count > 400/µl

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient aged 12-80 at date of last eosinophil count
* Asthma diagnosis at any time
* Blood Eosinophil reading in patient record (numeric count expressed in µl) at least one year prior to last data extraction
* Two years of continuous data