Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

NCT ID: NCT00454415

Last Updated: 2012-12-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 16000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2008-12-31

Brief Summary

Asthma is a common illness among children in the United States. While there are many known causes of asthma, including tobacco smoke, pollen, dust, or other allergens, the exact cause of asthma in some individuals remains unknown. This study will examine the role that specific dietary factors and body mass index (BMI) play in the development of childhood asthma.

Detailed Description

Asthma prevalence has steadily increased in the United States since the early 1980s, but the exact cause of this increase remains unknown. It is estimated that at least 8% of Americans have asthma. Although anti-inflammatory medications have proven effective for decreasing asthma exacerbations, there are few treatment options available to prevent the initial onset of the disease. Dietary factors and BMI may play a role in the development of asthma. Specifically, individuals who eat foods containing antioxidants (e.g., vitamin C, vitamin E, and carotenoids), n-3 polyunsaturated fatty acids (e.g., fish oils), and vitamin D may have a decreased risk of developing asthma, while individuals with higher BMI ratios may have an increased asthma risk. The purpose of this study is to evaluate the relationship among dietary factors, BMI, and the incidence of asthma among children.

This study will enroll children participating in the Growing Up Today study and children of nurses who are participating in the Nurses Health Study II. Researchers will analyze participants' previously completed questionnaires on dietary intake, physical activity, height, weight, and the presence of physician-diagnosed asthma. All participants with physician-diagnosed asthma will receive an additional asthma questionnaire. A small portion of these participants will also have their medical records reviewed by study researchers, and mothers of these children will be asked to complete a questionnaire. Additionally, a questionnaire will be sent to and completed by children who do not have asthma and their mothers.

Conditions

Asthma

Keywords

Diet; Body Mass Index; BMI

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Children of women in the Nurses Health Study II (NHS2)
• Participated in the Growing Up Today study

Exclusion Criteria

• None

• Minimum Eligible Age: 9 Years
• Maximum Eligible Age: 14 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: collaborator

Brigham and Women's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Carlos A. Camargo

Professor of Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Carlos A. Camargo, MD, DrPH

Role: PRINCIPAL_INVESTIGATOR

Channing Laboratory, Brigham and Women's Hospital

Locations

Channing Laboratory, Brigham and Women's Hospital

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

R01HL084401-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1376

Identifier Type: -

Identifier Source: org_study_id