Antipsychotic to Treat Psychosis Syndrome

NCT ID: NCT02137616

Last Updated: 2014-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2014-12-31

Brief Summary

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This study assess the safety and effects of atypical antipsychotics in subjects with psychosis syndrome and psychosis risk syndrome.

Detailed Description

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The investigators investigated whether administration of atypical antipsychotics could alleviate prodromal symptoms and be well tolerated by subjects with psychosis syndrome and psychosis risk syndrome.

Conditions

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Psychotic Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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risperidone

low dosage of antipsychotic drug

Group Type ACTIVE_COMPARATOR

risperidone

Intervention Type DRUG

Risperdal tablets

olanzapine

low doseage of antipsychotic

Group Type ACTIVE_COMPARATOR

olanzapine

Intervention Type DRUG

olanzapine tablets

quetiapine

low doseage of antipsychotic

Group Type ACTIVE_COMPARATOR

Quetiapine

Intervention Type DRUG

quetiapine tablets

aripiprazole

low doseage of antipsychotic

Group Type ACTIVE_COMPARATOR

Aripiprazole

Intervention Type DRUG

Aripiprazole tablets

Interventions

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risperidone

Risperdal tablets

Intervention Type DRUG

olanzapine

olanzapine tablets

Intervention Type DRUG

Quetiapine

quetiapine tablets

Intervention Type DRUG

Aripiprazole

Aripiprazole tablets

Intervention Type DRUG

Other Intervention Names

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Risperidol olanzapine tablets quetiapine tablets Aripiprazole tablets

Eligibility Criteria

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Inclusion Criteria

* were help-seeking young individuals in outpatients service
* aged 16-30 years
* fitted one of the following Criteria: Psychosis-risk Syndromes (COPS-SIPS) or Psychotic Syndrome (POPS-SIPS) or DSM-IV diagnosis of schizophreniform disorder

Exclusion Criteria

* a previous diagnosis of any psychotic disorder or bipolar disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition;
* symptoms fully accounted for by an Axis 1 disorder or sequelae of drug/alcohol use;
* neurological disorders or organic disorders affecting the central nervous system, substance-related disorders or mental retardation as defined by the DSM-IV criteria;
* history treatment of antipsychotic or antidepression, mood stabilizers or electroconvulsive therapy;
* diagnosed as having a serious and unstable medical condition.
Minimum Eligible Age

16 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central South University

OTHER

Sponsor Role lead

Responsible Party

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xiaofeng Guo

prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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xiaofeng Guo, Dr

Role: PRINCIPAL_INVESTIGATOR

the second xiangya hospitcal

Locations

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the Second Xiangya Hospital

Changsha, Hunan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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xiaofeng Guo, Dr.

Role: CONTACT

073185554052 ext. 073185554052

Facility Contacts

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Xiaofeng Guo, dr

Role: primary

073185554052 ext. 073185554052

Other Identifiers

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201002003

Identifier Type: -

Identifier Source: org_study_id

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