A Study of Paliperidone Palmitate in Patients With Schizophrenia Previously Unsuccessfully Treated by Oral Antipsychotics

NCT ID: NCT01685931

Last Updated: 2016-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

617 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2014-12-31

Brief Summary

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The purpose of this study is to assess the effectiveness, safety and tolerability of flexibly dosed paliperidone palmitate in patients with schizophrenia previously unsuccessfully treated by oral antipsychotics and with acute symptom of schizophrenia.

Detailed Description

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This is a 13-week, open-label (all people know the identity of the intervention), single-arm (one group of patients), multicenter, prospective, interventional study in Chinese patients. In a prospective, interventional study, the patients identified receive a treatment during the course of the research study and are followed forward in time for the outcome of the study. In China, there is still insufficient information about effectiveness, tolerability, and dosage strategy for directly switching from previous oral antipsychotics (drugs that are helpful in the treatment of psychosis and have a capacity to ameliorate thought disorders) in patients with acute symptoms. Acute symptoms are quick and severe form of illness in its early stage. In addition, there is also lack of information about bridging acute phase to long-term treatment. In this study, patients with multiple types of acute schizophrenia will be recruited and will receive Sustenna (paliperidone palmitate) treatments for 13 weeks. After the acute treatment, the patients will continue to receive the prescribed medication and will be followed up for an additional 52 weeks to assess the outcomes related to long-term treatment.

Conditions

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Schizophrenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Paliperidone Palmitate

Group Type EXPERIMENTAL

Paliperidone Palmitate

Intervention Type DRUG

One intramuscular injection of paliperidone palmitate flexible dose will be administered on Day 1, Day 8, and monthly thereafter.

Interventions

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Paliperidone Palmitate

One intramuscular injection of paliperidone palmitate flexible dose will be administered on Day 1, Day 8, and monthly thereafter.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Previous diagnosis of schizophrenia
* Experiencing an acute episode, with a Positive and Negative Syndrome Scale (PANSS) total score between 70 and 120, inclusive
* Patients currently treated with antipsychotic are allowed to be recruited
* Be medically stable on the basis of clinical laboratory tests performed at screening

Exclusion Criteria

* A primary diagnosis other than schizophrenia
* History of risperidone or paliperidone resistance as defined by failure to respond to 2 adequate treatment periods
* Clozapine use for treatment refractory schizophrenia
* Relevant history or current presence of any significant or unstable condition, disease or illness that could limit the participation in the study according to the investigator
* Woman who is pregnant, breast-feeding, or is planning to become pregnant within 6 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xian-Janssen Pharmaceutical Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xian-Janssen Pharmaceutical Ltd., China Clinical trial

Role: STUDY_DIRECTOR

Xian-Janssen Pharmaceutical Ltd.

Locations

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Baoding, , China

Site Status

Beijing, , China

Site Status

Chengdu, , China

Site Status

Chongqing, , China

Site Status

Fuzhou, , China

Site Status

Guangzhou, , China

Site Status

Hangzhou, , China

Site Status

Jinan, , China

Site Status

Nanjing, , China

Site Status

Qingdao, , China

Site Status

Shantou, , China

Site Status

Shenzhen, , China

Site Status

Shijiazhuang, , China

Site Status

Suzhou, , China

Site Status

Taiyuan, , China

Site Status

Tianjin, , China

Site Status

Wuhan, , China

Site Status

Countries

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China

Related Links

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http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_JNJ_7051&studyid=3548&filename=CR100880_CSR.pdf

A Study of Paliperidone Palmitate in Patients with Schizophrenia Previously Unsuccessfully Treated by Oral Antipsychotics

Other Identifiers

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R092670SCH4019

Identifier Type: OTHER

Identifier Source: secondary_id

CR100880

Identifier Type: -

Identifier Source: org_study_id

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