A Pilot Study of a Non-Invasive Neuromodulation Device for Treatment of Parkinson's Disease

NCT ID: NCT02134795

Last Updated: 2025-05-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2014-09-30

Brief Summary

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This is a single-center, open label study evaluating the acute effect of caloric vestibular stimulation on UPDRS motor scores in Parkinson's Disease patients.

Detailed Description

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Conditions

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Parkinson's Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Caloric Vestibular Stimulation (CVS)

Mild to moderate Parkinson's disease subjects will up to 3 sessions of 19 minutes each with the TNM Device during as many as 2 study visits: 2 sessions separated by 1 hour during the 1st study visit and 1 CVS session during a 2nd study visit.

Group Type EXPERIMENTAL

TNM Device

Intervention Type DEVICE

The noninvasive device is worn like a music headset and the patient lies back on a wedge pillow while the device is active. Each session lasts under 20 minutes.

Interventions

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TNM Device

The noninvasive device is worn like a music headset and the patient lies back on a wedge pillow while the device is active. Each session lasts under 20 minutes.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient should have a UPDRS motor score of 14 (off medication) or higher (mild to moderate)
* Patient should have a Hoehn \& Yahr staging of 1 to 3 (mild to moderate)
* Patient must be an adult (18 years of age or older)

Exclusion Criteria

* Women who are pregnant or nursing
* have a history of significant cardiovascular disease (no pacemakers)
* have a history of unstable mood disorder or unstable anxiety disorder or psychosis
* use a hearing aid
* have a cochlear implant
* have been diagnosed with neurological disease other than Parkinson's disease. No atypical parkinsonism.
* have a diagnosed vestibular dysfunction
* abuse alcohol or other drugs
* have had eye surgery within the previous three months or ear surgery within the previous six months
* have active ear infections or a perforated tympanic membrane
* have participated in another clinical trial within the last 30 days or are currently enrolled in another clinical trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Scion NeuroStim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Duke University Health System

Durham, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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Pro00053320

Identifier Type: -

Identifier Source: org_study_id

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