Procalcitonin Antibiotic Consensus Trial (ProACT)

NCT ID: NCT02130986

Last Updated: 2019-01-15

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1664 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-03

Study Completion Date

2017-07-21

Brief Summary

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The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory Tract Infection (LRTI).

Detailed Description

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There is a need for improved decision-making for antibiotic prescription in acute suspected infection. Infections, particularly in the early stages, can have protean manifestations, often do not manifest with "classic" signs, and clinically overlap with non-infectious conditions. However, the imperative to quickly give antibiotics for bacterial infection has led to antibiotic overuse and resistance.

Strategies that combine novel diagnostics with therapeutics have improved decision-making in oncology, cardiology, and other fields. These strategies aim to identify those patients most likely to be helped or harmed by the therapeutic intervention and allow more individualized care. This approach takes diagnostics to the next level, by demanding a test not only measure well, but also that clinical care be improved by tying the test to a treatment strategy.

Procalcitonin, a novel biomarker of bacterial infection, may help physicians make more appropriate antibiotic decisions. Lower respiratory tract infection (LRTI) is an ideal trial population. LRTI accounts for a large proportion of antibiotic prescription, and exemplifies the imprecise clinical phenotype of infection.However, key questions of generalizability and safety preclude widespread application.

Conditions

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Lower Respiratory Tract Infection (LRTI)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Procalcitonin (PCT) group

Procalcitonin (PCT) level; Results of procalcitonin level to treating clinician; Provide procalcitonin guideline to treating clinician; Telephone Visit at Day 15 and Day 30

Group Type EXPERIMENTAL

Telephone Visit

Intervention Type OTHER

We will collect the number of antibiotic days during telephone visits occurring on or around Day 15 and Day 30

Procalcitonin level

Intervention Type OTHER

A procalcitonin (PCT) will be drawn level within one hour after randomization in the ED, and if hospitalized, 6-24 hours after the initial ED blood draw, and on Days 3, 5, and 7. Days 3, 5, and 7 blood draws for procalcitonin will only occur in hospitalized patients on antibiotics and/or at the treating physician's discretion.

Results of procalcitonin (PCT) level to treating clinician

Intervention Type OTHER

In the ED, we will quickly (\<1 hour goal) provide clinicians the procalcitonin result.

Provide procalcitonin guideline to treating clinician

Intervention Type OTHER

Procalcitonin antibiotic guideline --

Procalcitonin level (ug/L) -- Bacterial etiology -- Recommendation

\< 0.1 -- Very unlikely -- Antibiotics strongly discouraged(1)

0.1 - 0.25 -- Unlikely -- Antibiotics discouraged(1)

\> 0.25 - 0.5 -- Likely -- Antibiotics recommended(2)

\> 0.5 -- Very likely -- Antibiotics strongly recommended(2)

1. Initial antibiotics can be considered for critical illness, Legionella pneumophilia. Procalcitonin should be evaluated in context with all findings and the total clinical status; clinical judgment always necessary.
2. For outpatients, antibiotic duration based on level (\> 0.25-0.5 ug/L:3 days; \> 0.5-1.0 ug/L:5 days; \>1.0 ug/L:7 days). Physician follow-up is recommended.

Usual Care group

Telephone Visit at Day 15 and Day 30

Group Type ACTIVE_COMPARATOR

Telephone Visit

Intervention Type OTHER

We will collect the number of antibiotic days during telephone visits occurring on or around Day 15 and Day 30

Interventions

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Telephone Visit

We will collect the number of antibiotic days during telephone visits occurring on or around Day 15 and Day 30

Intervention Type OTHER

Procalcitonin level

A procalcitonin (PCT) will be drawn level within one hour after randomization in the ED, and if hospitalized, 6-24 hours after the initial ED blood draw, and on Days 3, 5, and 7. Days 3, 5, and 7 blood draws for procalcitonin will only occur in hospitalized patients on antibiotics and/or at the treating physician's discretion.

Intervention Type OTHER

Results of procalcitonin (PCT) level to treating clinician

In the ED, we will quickly (\<1 hour goal) provide clinicians the procalcitonin result.

Intervention Type OTHER

Provide procalcitonin guideline to treating clinician

Procalcitonin antibiotic guideline --

Procalcitonin level (ug/L) -- Bacterial etiology -- Recommendation

\< 0.1 -- Very unlikely -- Antibiotics strongly discouraged(1)

0.1 - 0.25 -- Unlikely -- Antibiotics discouraged(1)

\> 0.25 - 0.5 -- Likely -- Antibiotics recommended(2)

\> 0.5 -- Very likely -- Antibiotics strongly recommended(2)

1. Initial antibiotics can be considered for critical illness, Legionella pneumophilia. Procalcitonin should be evaluated in context with all findings and the total clinical status; clinical judgment always necessary.
2. For outpatients, antibiotic duration based on level (\> 0.25-0.5 ug/L:3 days; \> 0.5-1.0 ug/L:5 days; \>1.0 ug/L:7 days). Physician follow-up is recommended.

Intervention Type OTHER

Other Intervention Names

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PCT level

Eligibility Criteria

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Inclusion Criteria

* ≥ 18 years old
* A primary clinical diagnosis in the ED of acute LRTI (\< 28 days duration)
* Clinician willing to consider procalcitonin in antibiotic decision-making

Exclusion Criteria

* Systemic antibiotics before ED presentation (All prophylactic antibiotic regimens, OR received \>1 dose within 72 hours prior to ED presentation)
* Current vasopressor use
* Mechanical ventilation (via endotracheal tube)
* Known severe immunosuppression
* Accompanying non-respiratory infections
* Known lung abscess or empyema
* Chronic dialysis
* Metastatic cancer
* Surgery in the past 7 days (excluding minor surgery such as skin biopsy)
* Incarcerated or homeless
* Enrolled in ProACT in the past 30 days
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of General Medical Sciences (NIGMS)

NIH

Sponsor Role collaborator

BioMérieux

INDUSTRY

Sponsor Role collaborator

University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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David T. Huang, MD, MPH

Associate Professor of Critcal Care and Emergency Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David T Huang, MD MPH

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Maricopa Medical Center

Phoenix, Arizona, United States

Site Status

University of California at Irvine Medical Center

Orange, California, United States

Site Status

Norwalk Hospital

Norwalk, Connecticut, United States

Site Status

University of Maryland/Baltimore

Baltimore, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Wayne State University/Detroit Receiving Hospital

Detroit, Michigan, United States

Site Status

Essentia Institute of Rural Health

Duluth, Minnesota, United States

Site Status

The Ohio State University, College of Medicine

Columbus, Ohio, United States

Site Status

Penn State Hershey College of Medicine; Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

References

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Huang DT, Yealy DM, Filbin MR, Brown AM, Chang CH, Doi Y, Donnino MW, Fine J, Fine MJ, Fischer MA, Holst JM, Hou PC, Kellum JA, Khan F, Kurz MC, Lotfipour S, LoVecchio F, Peck-Palmer OM, Pike F, Prunty H, Sherwin RL, Southerland L, Terndrup T, Weissfeld LA, Yabes J, Angus DC; ProACT Investigators. Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection. N Engl J Med. 2018 Jul 19;379(3):236-249. doi: 10.1056/NEJMoa1802670. Epub 2018 May 20.

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Reference Type DERIVED
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Provided Documents

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Document Type: Study Protocol and Informed Consent Form

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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1R01GM101197

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1R01GM101197

Identifier Type: NIH

Identifier Source: org_study_id

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