Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-15

Study Completion Date

2017-07-07

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. A significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. One brain imaging study showed an increase in opioid activity in athletes after endurance training. However , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . Consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects .

Preliminary results of a previous study the investigators are conducting on anorexia nervosa (AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. However, the relation of cause and effect between these anomalies and undernutrition remains to be determined . Given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Neurobiology of Opioid Dependence: 5 - 5

NCT00000196

Opioid-Related Disorders

WITHDRAWN PHASE2

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

NCT05463367

Opioid Use Opioid Dependence Opioid-use Disorder +8 more

ACTIVE_NOT_RECRUITING PHASE2

Multi-System Analysis of Opioid Receptor Binding

NCT05528848

Healthy Opioid Use Disorder

RECRUITING PHASE1

Tau PET Imaging in Opioid Use Disorder

NCT05651516

Opioid-Related Disorders

ACTIVE_NOT_RECRUITING EARLY_PHASE1

Effects of Dronabinol in Opioid Maintained Patients

NCT04025359

Pain

RECRUITING EARLY_PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sports Nutritional Sciences

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

sportswomen

3 micrograms \[11C\]diprenorphine

Group Type EXPERIMENTAL

[11C]diprenorphine

Intervention Type OTHER

3 micrograms \[11C\]diprenorphine - intravenous use - 1 time

control subjects

3 micrgrams \[11C\]diprenorphine

Group Type EXPERIMENTAL

[11C]diprenorphine

Intervention Type OTHER

3 micrograms \[11C\]diprenorphine - intravenous use - 1 time

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

[11C]diprenorphine

3 micrograms \[11C\]diprenorphine - intravenous use - 1 time

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

radiopharmacentical precursor solution

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

For High-level sportswomen :

* 18-35-year-old
* High-level sportswomen
* BMI\>19kg/m2
* Absence of eating disorders
* In pre-competition period
* Signature of written consent

For controls :

* 18-35-year-old
* Sedentary normal weight women
* BMI\>19kg/m2
* Normal nutritional markers
* Absence of eating disorders or other psychiatric or organic diseases

Exclusion Criteria

* Oral contraception
* Heart failure
* Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes