Effects of Dynorphin 1-13 on Heroin Addiction - 1

NCT ID: NCT00000244

Last Updated: 2015-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

1994-08-31

Study Completion Date

1997-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Opioid-Related Disorders Substance Withdrawal Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dynorphin 1 - 13

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

opiate addict between the ages of 18-55

Exclusion Criteria

Regular abuse of other drugs, unstable medical conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Paul Pentel, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

U of Minnesota School of Medicine

Minneapolis, Minnesota, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Specker S, Wananukul W, Hatsukami D, Nolin K, Hooke L, Kreek MJ, Pentel PR. Effects of dynorphin A(1-13) on opiate withdrawal in humans. Psychopharmacology (Berl). 1998 Jun;137(4):326-32. doi: 10.1007/s002130050626.

Reference Type BACKGROUND
PMID: 9676891 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

R01DA008067

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01-08067-1

Identifier Type: -

Identifier Source: secondary_id

NIDA-08067-1

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Buprenorphine Dose Alteration Study - 1
NCT00000219 COMPLETED PHASE1
Effects of Dronabinol in Opioid Maintained Patients
NCT04025359 RECRUITING EARLY_PHASE1
Neurobiology of Opioid Dependence: 2 - 2
NCT00000193 WITHDRAWN PHASE2
Neurobiology of Opioid Dependence: 4 - 4
NCT00000195 WITHDRAWN PHASE2
Abuse Potential of Buprenorphine/Naloxone
NCT00149539 TERMINATED PHASE2
Buprenorphine's Dose Response Curve
NCT00460239 COMPLETED PHASE2
Neurobiology of Opioid Dependence: 5 - 5
NCT00000196 WITHDRAWN PHASE2