Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

NCT ID: NCT02104817

Last Updated: 2021-08-17

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

13078 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-30

Study Completion Date

2020-05-27

Brief Summary

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The study is a randomized, double-blind, placebo-controlled (corn oil), parallel group design that will enroll approximately 13,000 patients with hypertriglyceridemia and low HDL and high risk for CVD to be randomized 1:1 to either corn oil + statin or Epanova + statin, once daily, for approximately 3-5 years as determined when the number of MACE outcomes is reached.

Detailed Description

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Conditions

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Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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EPANOVA

Epanova + statin, once daily

Group Type EXPERIMENTAL

Epanova® (omega-3 carboxylic acids)

Intervention Type DRUG

Adjunct to statin therapy and diet in high risk adult patients for the prevention and reduction of major adverse cardiovascular events (MACE)

Corn oil

Corn oil + Statin

Group Type ACTIVE_COMPARATOR

corn oil control

Intervention Type DRUG

corn oil control arm

Interventions

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Epanova® (omega-3 carboxylic acids)

Adjunct to statin therapy and diet in high risk adult patients for the prevention and reduction of major adverse cardiovascular events (MACE)

Intervention Type DRUG

corn oil control

corn oil control arm

Intervention Type DRUG

Other Intervention Names

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omega-3 carboxylic acids

Eligibility Criteria

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Inclusion Criteria

1. Men or women, ≥18 years of age.
2. Patient must be on a stable diet and statin\* therapy at least 4 weeks prior to randomization (Visit 2) and meet the following criteria:

1. LDL-C \<100 mg/dL
2. TG level ≥180 and \<500 mg/dL and HDL-C \<42 mg/dL for men or HDL-C \<47 mg/dL for women
3. Patient is at high risk for a future cardiovascular event if at least one of the following criteria (3a, 3b or 3c)\* is present via patient history, physical exam, or medical records at the time of screening:

1. Any atherosclerotic CVD as defined in protocol.
2. History of diabetes mellitus (type 1 or 2) and ≥40 years of age for men and ≥50 years of age for women, plus one of the risk factors defined in protocol.
3. Male patients \>50 years of age or females \>60 years of age, with at least one of the risk factors defined in protocol.

Exclusion Criteria

1\. Allergy or intolerance to omega-3 carboxylic acids, omega-3 fatty acids, omega-3-acid ethyl esters, or corn oil. 2.Use of fibrates, bile acid sequestrants, or niacin or its analogues (\>250 mg/day) within 4 weeks prior to Visit 2. 3.Statin naïve at Visit 1.
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Cleveland Clinic

OTHER

Sponsor Role collaborator

IQVIA RDS Inc.

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Steven Nissen, MD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Michael Lincoff, MD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Stephen Nicholls, MD

Role: PRINCIPAL_INVESTIGATOR

MonashHeart

Locations

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Birmingham, Alabama, United States

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Birmingham, Alabama, United States

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Birmingham, Alabama, United States

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Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Muscle Shoals, Alabama, United States

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Chandler, Arizona, United States

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Gilbert, Arizona, United States

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Glendale, Arizona, United States

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Mesa, Arizona, United States

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Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Tempe, Arizona, United States

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Tucson, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Little Rock, Arkansas, United States

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Carlsbad, California, United States

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Fresno, California, United States

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Fresno, California, United States

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Greenbrae, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Milpitas, California, United States

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Newport Beach, California, United States

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Northridge, California, United States

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Palm Springs, California, United States

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San Diego, California, United States

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Santa Ana, California, United States

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Santa Rosa, California, United States

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Tarzana, California, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Waterbury, Connecticut, United States

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Boca Raton, Florida, United States

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Clearwater, Florida, United States

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Coral Gables, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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Pembroke Pines, Florida, United States

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Pensacola, Florida, United States

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Pinellas Park, Florida, United States

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Marietta, Georgia, United States

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Sandy Springs, Georgia, United States

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Savannah, Georgia, United States

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Arlington Heights, Illinois, United States

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Burke, Virginia, United States

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Green Bay, Wisconsin, United States

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La Crosse, Wisconsin, United States

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Madison, Wisconsin, United States

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Wausau, Wisconsin, United States

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Adelaide, , Australia

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Blacktown, , Australia

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Box Hill, , Australia

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Cowra, , Australia

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Southport, , Australia

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Wollongong, , Australia

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Bruges, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Mol, , Belgium

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Mons, , Belgium

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New Westminster, British Columbia, Canada

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Vancouver, British Columbia, Canada

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Barrie, Ontario, Canada

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Beijing, , China

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Harderwijk, , Netherlands

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Bloemfontein, , South Africa

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Port Elizabeth, , South Africa

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Potchefstroom, , South Africa

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Cherkasy, , Ukraine

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Ivano-Frankivsk, , Ukraine

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Uzhhorod, , Ukraine

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Airdrie, , United Kingdom

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Chelmsford, , United Kingdom

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Reading, , United Kingdom

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Romford, , United Kingdom

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Swansea, , United Kingdom

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Torquay, , United Kingdom

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United States Australia Belgium Canada China Czechia Denmark Estonia Hungary Italy Japan Lithuania Mexico Netherlands New Zealand Poland Russia South Africa South Korea Taiwan Ukraine United Kingdom

References

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Nissen SE, Lincoff AM, Wolski K, Ballantyne CM, Kastelein JJP, Ridker PM, Ray KK, McGuire DK, Mozaffarian D, Koenig W, Davidson MH, Garcia M, Katona BG, Himmelmann A, Loss LE, Poole M, Menon V, Nicholls SJ. Association Between Achieved omega-3 Fatty Acid Levels and Major Adverse Cardiovascular Outcomes in Patients With High Cardiovascular Risk: A Secondary Analysis of the STRENGTH Trial. JAMA Cardiol. 2021 Aug 1;6(8):910-917. doi: 10.1001/jamacardio.2021.1157.

Reference Type DERIVED
PMID: 33993205 (View on PubMed)

Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, Davidson MH, Kastelein JJP, Koenig W, McGuire DK, Mozaffarian D, Ridker PM, Ray KK, Katona BG, Himmelmann A, Loss LE, Rensfeldt M, Lundstrom T, Agrawal R, Menon V, Wolski K, Nissen SE. Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial. JAMA. 2020 Dec 8;324(22):2268-2280. doi: 10.1001/jama.2020.22258.

Reference Type DERIVED
PMID: 33190147 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2014-001069-28

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

D5881C00004

Identifier Type: -

Identifier Source: org_study_id

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