Comparison of Biodegradable Stents: Orsiro and BioMatrix

NCT ID: NCT02084901

Last Updated: 2016-07-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2016-03-31

Brief Summary

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The use of a biodegradable polymer has the potential to reduce the sustained inflammatory response of the arterial wall, facilitating re-endothelialization and minimizing the risk of thrombus formation and late restenosis. In the study, we are going to two biodegradable polymer stents, Orsiro and BioMatrix, especially regarding the stent strut coverage by optical coherence tomography at 3 months after stent implantation.

The primary objective of this study is to test the hypothesis that Orsiro is non-inferior to Biomatrix in terms of stent strut coverage by optical coherence tomography at 3 months. The secondary endpoint is clinical outcomes up to 1 year.

Detailed Description

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The use of a biodegradable polymer has the potential to reduce the sustained inflammatory response of the arterial wall, facilitating re-endothelialization and minimizing the risk of thrombus formation and late restenosis. In the study, we are going to two biodegradable polymer stents, Orsiro and BioMatrix, especially regarding the stent strut coverage by optical coherence tomography at 3 months after stent implantation.

The primary objective of this study is to test the hypothesis that Orsiro is non-inferior to Biomatrix in terms of stent strut coverage by optical coherence tomography at 3 months. The secondary endpoint is clinical outcomes up to 1 year.

Conditions

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All-comer Percutaneous Coronary Intervention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Orsiro Arm

Group Type EXPERIMENTAL

Drug-eluting biodegradable stent Orsiro implantation

Intervention Type DEVICE

Drug-eluting biodegradable stent Orsiro implantation

BioMatrix or BioMatrix Flex Arm

Group Type ACTIVE_COMPARATOR

Drug-eluting biodegradable stent BioMatrix or BioMatrix Flex implantation

Intervention Type DEVICE

Drug-eluting biodegradable stent BioMatrix or BioMatrix Flex implantation

Interventions

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Drug-eluting biodegradable stent Orsiro implantation

Drug-eluting biodegradable stent Orsiro implantation

Intervention Type DEVICE

Drug-eluting biodegradable stent BioMatrix or BioMatrix Flex implantation

Drug-eluting biodegradable stent BioMatrix or BioMatrix Flex implantation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patients ≥ 20 years old
2. Patients in the treatment of subjects with all-comer who are to undergo PCI

Exclusion Criteria

1. Pregnant women or women with potential childbearing
2. Life expectancy \< 1 year
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seodaemun-gu, Shinchondong

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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1-2013-0083

Identifier Type: -

Identifier Source: org_study_id

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